80447-71-8

Upstream product

• 924-44-7 glyoxylic acid ethyl ester 
• 59-88-1 phenylhydrazine hydrochloride 
• 996-82-7 sodium diethylmalonate 
• 100-34-5 benzene diazonium chloride 
• 28663-68-5 ethyl (phenylhydrazono)chloroacetate 
• 536-74-3 phenylacetylene 
• 10475-63-5 3-oxo-2-(phenylhydrazono)butyric acid ethyl ester 
• 1268701-25-2 ethyl 3-hydroxy-3-phenyl-2-(phenylhydrazono)propanoate 
• 69457-02-9 ethyl 3-hydroxy-2-(phenylhydrazono)butyrate 
• 40885-33-4 ethyl 2,3-dioxo-3-phenylpropanoate 2-phenylhydrazone 
• 100-63-0 phenylhydrazine 

Downstream Products

• 176662-48-9 1,5-diphenyl-3-ethoxycarbonylformazan 
• 6000-60-8 phenylhydrazonoacetic acid 
• 1383737-82-3 C₃₄H₃₅N₃O₅ 
• 1383737-83-4 C₃₇H₄₁N₃O₅ 
• 1421357-48-3 ethyl 5-(2-methoxy-2-oxoethyl)-1-phenyl-1H-pyrazole-3-carboxylate 
• 28663-68-5 ethyl (phenylhydrazono)chloroacetate 
• 1450908-85-6 (R)-ethyl 6-methyl-1,4-diphenyl-1,4-dihydropyridazine-3-carboxylate 

Relevant academic research and scientific papers

Pyrrolo[3,4-c]pyrazole Synthesis via Copper(?) Chloride-Catalyzed Oxidative Coupling of Hydrazones to Maleimides

A variety of pyrrolo[3,4-c]pyrazole derivatives from readily available aldehyde hydrazones and maleimides via direct oxidative coupling under radical cascade reaction have been reported. This method offers satisfactory chemical yields and good functional

Palladium and Copper Cocatalyzed Intermolecular Cyclization Reaction: Synthesis of 5-Aminopyrazole Derivatives

A novel and efficient palladium and copper co-catalyzed intermolecular cyclization of acetonitriles with hydrazones has been developed for the synthesis of 5-aminopyrazoles through C-C and C-N bond formation. The reaction has the advantages of easily avai

Silver(I)-Catalyzed Tandem Sigamatropic Rearrangement/1,3-H Shift/6π Aza-electrocyclization of N-Propargylic Hydrazones: A Mild Synthetic Route to 1,6-Dihydropyridazines

A highly efficient AgOTf catalyzed [3,3] sigmatropic rearrangement/1,3-H shift/6' aza-electrocyclization cascade reaction of N-propargylic hydrazones has been developed. This method provides a new mild synthetic route to various polysubstituted 1,6-dihydr

Radical Addition of Hydrazones by α-Bromo Ketones to Prepare 1,3,5-Trisubstituted Pyrazoles via Visible Light Catalysis

A novel efficient tandem reaction of hydrazones and α-bromo ketones is reported for the preparation of 1,3,5-trisubstituted pyrazoles by visible light catalysis. In this system, the monosubstituted hydrazones show wonderful reaction activity with alkyl radicals, generated from α-bromo ketones. A radical addition followed by intramolecular cyclization affords the important pyrazole skeleton in good to excellent yields. This efficient strategy under mild conditions with wide group tolerance provides a potential approach to the 1,3,5-trisubstituted pyrazoles.

Vinylogous reactivity of enol diazoacetates with donor-acceptor substituted hydrazones. Synthesis of substituted pyrazole derivatives

A regiospecific synthesis of multifunctional pyrazoleshas been developed from a cascade process triggered by Rh(II)-catalyzed dinitrogen extrusion from enol diazoacetates with vinylogous nucleophilic addition followed by Lewis acid catalyzed cyclization a

Catalytic asymmetric construction of chiral hydropyridazines via conjugate addition of N-monosubstituted hydrazones to enones

The first example of a highly enantioselective and scalable formal diaza-ene reaction between N-monosubstituted hydrazones and enones catalyzed by a simple chiral primary-second diamine salt has been developed. The catalytic process provides a highly prac

Pyrolysis of 3-hydroxy-2-arylhydrazonoalkanoic acid derivatives

1,2-Diaza-1,3-butadienes have been obtained from readily available 3-hydroxy-2-arylhydrazonopropanoates under various reaction conditions including pyrolysis, dehydration under Mitsunobu conditions or with acetic anhydride or acetic acid. According to their method of synthesis these 1,2-diaza-1,3- butadienes underwent subsequent reactions to give interesting products, and in the presence of proper dienophiles gave the corresponding cycloaddition products. Also, a new approach to pyrazole-3-carboxylic acid derivatives was discovered during an attempt to dehydrate 3-hydroxy-2-arylhydrazonobutanoic esters.

Gas-Phase Kinetics of Elimination Reactions of Pentane-2,4-Dione Derivatives

Gas-phase elimination reactions of pentane-2,4-dione, methyl acetoacetate, ethyl acetoacetate, 3-phenylhydroazopentane-2,4-dione, and ethyl 3-oxo-2-phenylhydrazonobutyrate have been measured in the temperature ranges of 744-783, 662-695, 614-663, 604-664, and 503-555 K, respectively, using a flow-thermolysis technique.These compounds undergo unimolecular first-order elimination reactions, for which log A = 11.9, 11.2, 11.7, 11.5, and 11.7 s-1 and Ea = 198.3, 167.1, 141.7, 165.6, and 141.7 kJ mol-1, respectively.The kinetic data and product analysis shows that the reactions are highly affected by the electronic nature of the substituents at the carbonyl and methylene carbon atoms of the substrates investigated.

α,β-UNSATURATED THIOLATES AND THEIR ANALOGS IN CYCLOADDITION REACTIONS. XVIII. REACTION OF 2-PHENYLETHYNYLTELLUROLATES WITH C-ETHOXYCARBONYL-N-PHENYLNITRILIMINE

The reaction of sodium or lithium 2-phenylethynyltellurolates with C-ethoxycarbonyl-N-phenylnitrilimine leads to the oxidation product of ethynyltellurolate - di(2-phenylethynyl)telluride, a product of reduction of the initial nitrilimine - the phenylhydr

Reactions of Aromatic Diazonium Salts with Diethyl Sodiomalonate

Benzenediazonium chloride and m-toluenediazonium chloride react with sodium salt of diethyl malonate in aqueous ethanol to give the coupling products (I and V) as the major products, along with the products (II, III, IV, VI) apparently derived from the coupling products.All the products obtained have been fully characterised by IR and PMR data.