6946-67-4Relevant academic research and scientific papers
Carboxamidation of carboxylic acids with 1-tert-butoxy-2-tert-butoxycarbonyl-1,2-dihydroisoquinoline (BBDI) without bases
Saito, Yukako,Ouchi, Hidekazu,Takahata, Hiroki
experimental part, p. 11129 - 11135 (2009/04/11)
Formation of carboxamides of a variety of carboxylic acids with the coupling reagent BBDI is described. This procedure permits a one pot and simple operation without the need of any bases and no base was?required for even use of amine hydrochlorides. In addition, an approach to BBDI-catalyzed carboxamidation is examined.
Analogues of 8-amino>-6-methoxy-4-methylquinoline as Candidate Antileishmanial Agents
LaMontagne, Maurice P.,Dagli, Dinesh,Khan, M. Sami,Blumbergs, Peter
, p. 981 - 985 (2007/10/02)
8-amino>-6-methoxy-4-methylquinoline (I) has been shown to be highly effective against Leishmania donovani in hamsters, being approximately 475 times as active as the standard meglumine antimoniate.Several nuclear and side-chain analogues of I have been prepared in an attempt to further enhance the antileishmanial activity of this class of compounds.The compounds were tested against L. donovani in the golden hamster.Although several analogues had meglumine antimoniate indexes in excess of 300, none was superior to the model compound.
