6946-90-3Relevant academic research and scientific papers
Kinetics and quantitative structure-activity relationships for pseudomonas sp. Lipase-catalyzed hydrolysis of both monoesters and diesters of ethylene glycol
Chiou, Shyh-Ying,Cheng, Yu-Ru,Lu, Chun-Ping,Lin, Yan-Fu,Lin, Long-Yau,Lin, Gialih
, p. 201 - 207 (2007/10/03)
The goal of this work is to study kinetics and quantitative structure-activity relationships for steady states of Pseudomonas sp. lipase-catalyzed hydrolysis of both diesters and monoesters of ethylene glycol. Based on the steady-state kinetics of the enzyme-catalyzed hydrolysis of the diesters of ethylene glycol, the diesters and the monoesters react simultaneously as soon as monoester has started to build up in the reaction medium. In other words, the apparent Km values of the diesters are the Km values of the diesters (KmA) plus the Km values of the monoesters (KmB), and all Vmax values are about the same. Moreover, the pH-stat titration curve of the enzyme-catalyzed hydrolysis of the diesters of ethylene glycol is initially hyperbolic, then there is a sharp falloff in the hydrolysis rate. The abrupt stoppage of the reaction (relaxation stage) may be due to the existence of two phases in the reaction medium, that is, the product (ethylene glycol) and the substrates (the diesters of ethylene glycol) are not miscible. Furthermore, quantitative structure-activity relationships for varied acyl groups of mono- and diesters of ethylene glycol are studied. The fact that both pKmA and pK mB values are linearly correlated with the hydrophobicity constant (π) but not with the electronic substituent constants (σ*) indicates that the affinity of these substrates for the enzyme depends only on the hydrophobicitv of substrates. Copyright
Photochemical Reaction of Benzene-1,2,4,5-tetracarbonitrile with the Ketals of Cyclic and Bicyclic Ketones
Mella, Mariella,Freccero, Mauro,Albini, Angelo
, p. 1047 - 1052 (2007/10/02)
The radical cations of the ethylene ketals of some cyclic and bicyclic ketones are generated by single electron transfer to excited benzene-1,2,4,5-tetracarbonitrile (TCB).Their fragmentation yields 1,5- and 1,6-distonic radical cations, which add to TCB(-.) to give alkyl>benzenetricarbonitriles.The reduction of the radical center occurs only to a small extent, and is enhanced in the presence of dodecylmercaptan, in the case of hindered radicals.The reaction of the camphor ethylene ketal (both alkylation of TCB and reduction) occurs with total diastereoselectivity at the reacting radical center.
