69466-55-3

Usage

InChI:InChI=1/C8H7N3OS/c1-13-8-10-6(5-9-11-8)7-3-2-4-12-7/h2-5H,1H3

Upstream product

• 17090-71-0 furan-2-yl-oxo-acetaldehyde 
• 110-00-9 furan 
• 28735-21-9 3-methylthio-1,2,4-triazine 
• 51445-63-7 oxo-thiophen-2-yl-acetaldehyde 

Downstream Products

• 69466-63-3 3-Methoxy-5-(2'-furyl)-1,2,4-triazin 
• 832686-56-3 1,6-dihydro-5-(2-furanyl)-6-(p-methoxyphenyl)-3-methylsulfanyl-1,2,4-triazine 

Relevant academic research and scientific papers

C-H-Functionalization of 1,2,4-triazines: Oxidation and elimination pathways of aromatization of σh-adducts

An approach to the synthesis of 1,2,4-triazine thienyl and furyl derivatives through the reaction of aromatic nucleophilic substitution of hydrogen was suggested. Oxidation and cine-elimination pathways of aromatization of the intermediate σH-a

A general approach to selective functionalization of 1,2,4-triazines using organometallics in palladium-catalyzed cross-coupling and addition reactions

A selective way to obtain disubstituted 1,2,4-triazines in good yields by combining addition reactions and palladium-catalyzed cross-coupling reactions of organometallics with 3-methylsulfanyl-1,2,4-triazine is described.

Pharmacologically active substituted 1,2,4-triazines

Substituted 1,2,4-triazines, compositions thereof and methods of using same are described. The compounds of the invention exhibit a wide range of pharmacological activity including anti-inflammatory, analgesic, anti-pyretic, hypotensive and central nervous system effects.