69466-88-2

Usage

InChI:InChI=1/C16H11Cl2N3S/c1-22-16-19-14(10-2-6-12(17)7-3-10)15(20-21-16)11-4-8-13(18)9-5-11/h2-9H,1H3

Upstream product

• 35600-34-1 S-methyl isothiosemicarbazide hydroiodide 
• 3457-46-3 4,4'-dichlorobenzil 
• 79-19-6 thiosemicarbazide 
• 74-88-4 methyl iodide 
• 44387-06-6 methyl hydrazinecarbimidothioate 

Downstream Products

• 69467-22-7 3-methoxy-5,6-bis(p-chlorophenyl)-1,2,4-triazine 
• 74930-12-4 5,6-Bis-(4-chloro-phenyl)-3-methylsulfanyl-2,5-dihydro-[1,2,4]triazine 
• 74930-13-5 5,6-Bis-(4-chloro-phenyl)-3-methoxy-2,5-dihydro-[1,2,4]triazine 
• 74930-20-4 5,6-Bis-(4-chloro-phenyl)-2-methyl-3-methylsulfanyl-2,5-dihydro-[1,2,4]triazine 
• 74930-21-5 (S)-5,6-Bis-(4-chloro-phenyl)-3-methoxy-2-methyl-2,5-dihydro-[1,2,4]triazine 

Relevant academic research and scientific papers

CO2-assisted synthesis of non-symmetric α-diketones directly from aldehydes: Via C-C bond formation

CO2-assisted various symmetric and non-symmetric α-diketones have been synthesized directly from the corresponding aldehydes using transition metal-free catalysts. This method can even be applied to synthesize pharmaceuticals directly from aldehydes. The crucial role of CO2 has been investigated in detail and the mechanism is proposed on the basis of experiments and DFT calculations.

Design, green synthesis and pharmacological evaluation of novel 5,6-diaryl-1,2,4-triazines bearing 3-morpholinoethylamine moiety as potential antithrombotic agents*

The aim of this research work was to investigate a series of novel 5,6-diaryl-1,2,4-triazines (3a–3q) containing 3-morpholinoethylamine side chain, and to address their antiplatelet activity by in vitro, ex vivo and in vivo methods. All compounds were syn

In vitro antitumor activity evaluation of some 1,2,4-triazine derivatives bearing piperazine amide moiety against breast cancer cells

A series of 1,2,4-triazine derivatives bearing piperazine amide moiety has been synthesized and investigated for their potential anticancer activities. 1-[4-(5,6-Bis(4-subtituted phenyl)-1,2,4-triazin-3-yl)piperazin-1-yl]-2-[4-(3-substituted phenyl)pipera

Microwave-assisted synthesis and anticonvulsant activity of 5,6-bisaryl-1,2,4-triazine-3-thiolderivatives

A series of 5,6-bisaryl-1,2,4-triazine-3-thiol derivatives were synthesized through microwave-promoted chemistry by condensation of the aromatic 1,2-diketones and thiosemicarbazide in a mixed green solvent. Subsequently, S-alkylation of 1,2,4-triazine-3-t

Room-temperature ionic liquid-DMSO promoted and improved one-pot synthesis of 5,6-diaryl-1,2,4-triazines

An improved and rapid one-pot synthesis of 5,6-diarylsubstituted-1,2,4- triazines in a mixture of room-temperature ionic liquid 1,3-dibutylimidazolium bromide [Bbim]+Br- and dimethylsulfoxide (DMSO) is described without the need for

Synthesis and in vitro evaluation of novel 1,2,4-triazine derivatives as neuroprotective agents

The role of novel triazine derivatives against oxidative stress exerted by hydrogen peroxide on differentiated rat pheochromocytoma (PC12) cell line was examined and a consistent protection from H2O2-induced cell death, associated with a marked reduction in caspase-3 activation, was observed. Moreover, activation of NF-κB, a known regulator of a host of genes that involves in specific stress and inflammatory responses by H2O2, was greatly impaired by triazine pretreatment in differentiated PC12 cells. Neuroprotective effect of such compounds may represent a promising approach for treatment of neurodegenerative diseases.

Diaryl-pyrazine derivatives affecting GABA binding

This invention relates to certain amino-5,6-diarylpyrazines useful as activators of GABA and benzodiazepine binding.

1,2,4-Triazine Chemistry. 10. Dihydro-1,2,4-triazines: Structural Studies of 5,6-Diaryldihydro-1,2,4-triazines through the Reactions with Dimethyl Acetylenedicarboxylate

Sodium borohydride reduction of 3-(methylthio)-5,6-diphenyl- (1a), 3-(methylthio)-5,6-ditolyl- (1c), 3-(methylthio)-5,6-dianisyl- (1e), and 3-(methylthio)-5,6-bis(p-chlorophenyl)-1,2,4-triazine (1g) afforded the corresponding 2,5-dihydro-1,2,4-triazines (

Pharmacologically active substituted 1,2,4-triazines

Substituted 1,2,4-triazines, compositions thereof and methods of using same are described. The compounds of the invention exhibit a wide range of pharmacological activity including anti-inflammatory, analgesic, anti-pyretic, hypotensive and central nervous system effects.