69467-92-1Relevant articles and documents
A short synthesis of 9-fluoroellipticine from 5-fluoroindole?
Davis, Deborah A.,Gribble, Gordon W.
, p. 422 - 430 (2019/07/31)
A synthesis of 9-fluoroellipticine (1c) from 5-fluoroindole (6) is described that features the regioselective lithiation of 5-fluoro-1-(phenylsulfonyl)indole (7) followed by chemoselective acylation of 3,4-pyridinedicarboxylic anhydride. Subsequent cyclization of keto acid 9 to keto lactam 10 with acetic anhydride and sequential treatment of 10 with methyllithium and sodium borohydride affords 9-fluoroellipticine.