69467-92-1

Upstream product

• 917-54-4 methyllithium 
• 153616-18-3 N-p-fluorophenyl-2,5-dimethyl-N-p-tosylaniline 
• 153616-16-1 6-fluoro-1,4-dimethyl-9-H-carbazole-3-carbaldehyde 
• 128612-26-0 6-fluoro-1,4-dimethyl-9-H-carbazole 
• 727-31-1 N-(4-fluorophenyl)-4-methylbenzenesulfonamide 
• 553-94-6 4-bromo-m-xylene 
• 153616-19-4 3--6-fluoro-1,4-dimethylcarbazole 

Relevant academic research and scientific papers

A short synthesis of 9-fluoroellipticine from 5-fluoroindole?

A synthesis of 9-fluoroellipticine (1c) from 5-fluoroindole (6) is described that features the regioselective lithiation of 5-fluoro-1-(phenylsulfonyl)indole (7) followed by chemoselective acylation of 3,4-pyridinedicarboxylic anhydride. Subsequent cyclization of keto acid 9 to keto lactam 10 with acetic anhydride and sequential treatment of 10 with methyllithium and sodium borohydride affords 9-fluoroellipticine.

A Flexible Approach to Pyridocarbazoles. The Syntheses of 8,10-Dimethoxy-5-methyl-, 5,11-Dimethoxy-7,10-dimethyl- and 9-fluoro-5,11-Dimethylpyridocarbazoles by Variations of the 'Type D' Route

Syntheses of three different pyridocarbazoles are described.Palladium acetate oxidation of 4-cyano-N-(3,5-dimethoxyphenyl)-2-methylaniline 19 and reduction of the resultant 3-cyano-4,6-dimethoxy-1-methylcarbazole 23 with diisobutylaluminium hydride gave t