69478-77-9

Usage

Uses

Used in Organic Synthesis:
3-(DIMETHYLAMINO)PYRROLIDINE is used as a reagent in organic synthesis for its ability to participate in a wide range of reactions, facilitating the creation of pharmaceuticals and other fine chemicals.
Used in Pharmaceutical Preparation:
In the pharmaceutical industry, 3-(DIMETHYLAMINO)PYRROLIDINE is utilized as a reagent, capitalizing on its nucleophilic nature to aid in the synthesis of various medicinal compounds.
Used in Asymmetric Synthesis:
3-(DIMETHYLAMINO)PYRROLIDINE is employed as a chiral auxiliary in enantioselective processes, contributing to the production of enantiomerically pure compounds, which is crucial for the development of effective and safe drugs.
Used in Chemical Catalysis:
As a catalyst, 3-(DIMETHYLAMINO)PYRROLIDINE is used in certain chemical transformations to enhance reaction rates and selectivity, thereby improving the efficiency of chemical processes in various industries.

Upstream product

• 116183-79-0 (3S)-3-<(4-tolylsulfonyl)oxy>-1-(phenylmethyl)pyrrolidine 
• 124-40-3 dimethyl amine 
• 101385-90-4 (S)-N-benzyl-3-hydroxypyrrolidine 
• 50-00-0 formaldehyd 
• 114715-39-8 (R)-1-benzyl-3-aminopyrrolidine 
• 116183-80-3 (3R)-3-<(4-tolylsulfonyl)oxy>-1-(phenylmethyl)pyrrolidine 
• 116143-02-3 (3R)-1-(phenylmethyl)pyrrolidin-3-ol Acetate 
• 101385-90-4 (R)-N-benzyl-3-hydroxypyrrolidine 

Downstream Products

• 50534-42-4 (S)-(-)-3-dimethylaminopyrrolidine dihydrochloride 
• 50534-42-4 3-(R)-(N,N-dimethylamino)pyrrolidine dihydrochloride 

Relevant academic research and scientific papers

Chiral 3-aminopyrrolidines as a rigid diamino scaffold for organocatalysis and organometallic chemistry

Over 20 new and easily prepared diamines were screened for the asymmetric Morita-Baylis-Hillman reaction. Chiral non-racemic 3-(N,N-dimethylamino)-1- methylpyrrolidine was found to promote efficiently the reaction of methyl vinyl ketone and substituted benzaldehydes. Enantiomeric excesses up to 73% were reached with electron-deficient benzaldehyde derivatives. After a simple deprotonation, one of these diamines was transformed into a chiral mixed aggregate for the enantioselective synthesis of (R)-1-o-tolylethanol with 76% ee.

Fluoronaphthyridines and -quinolines as Antibacterial Agents. 5. Synthesis and Antimicrobial Activity of Chiral 1-tert-Butyl-6-fluoro-7-substituted-naphthyridones

A series of novel 7-substituted-1-tert-butyl-6-fluoronaphthyridone-3-carboxylic acids has been prepared.These derivatives are characterized by chiral aminopyrrolidine substituents at the 7 position.In this paper we report the full details of the asymmetric synthesis of this series of compounds.Structure-activity relationship studies indicate that the absolute stereochemistry at the asymmetric centers of the pyrrolidine ring is critical for maintaining good activity.Compounds 60 and 61 (3-amino-4-methylpyrrolidine enantiomers) were selected for preclinical evaluation.

Dibenzo-epines: Effect of the basic side-chain on neuroleptic activity

Structure-activity relationships in a series of dibenzo[b,f][1,4]thiazepines and -oxazepines and dibenzo[b,e][1,4]diazepines having different basic substituents in the 11-position were studied with reference to their neuroleptic activity. A high degree of structure-specificity was found for the piperazinyl moiety as well as for the distances between the distal nitrogen atom of this group and the tricyclic ring system, which distances are probably of importance for receptor binding. It was shown that the N-oxides of the neuroleptic agents clotiapine, loxapine and clozapine were inactive in in vitro binding tests involving central dopaminergic receptors, and it is very likely therefore that the in vivo activity of these N-oxides in the rat is due to their enzymatic reduction to the active parent compounds. All derivatives having a basic side-chain other than N-alkylpiperazinyl were inactive neuroleptically, with the exception of the N-methyl-4-piperidyl derivative which showed relatively weak effects.