69483-37-0Relevant academic research and scientific papers
On the preparation of some phospholipid analogues
Browne, Judith E.,Freeman, Richard T.,Russell, Jeremy C.,Sammes, Peter G.
, p. 645 - 652 (2007/10/03)
Several structural analogues of the biocompatible diacyl glycerol phosphatidylcholine family have been prepared. Considerable variation in structure is allowed without impairing the desirable biocompatible properties. In particular, derivatives in which the fatty ester link is replaced by ether links and in which the central glycerol group is replaced by simple variants such as the symmetrical tris(hydroxymethyl)ethane group retain biocompatible properties. The Royal Society of Chemistry 2000.
A lipid-lipase aggregate with ether linkage as a new type of immobilized enzyme for enantio-selective hydrolysis in organic solvents
Akita,Umezawa,Matsukura,Oishi
, p. 318 - 324 (2007/10/02)
For the purpose of carrying out smoothly enzymatic reaction of water-insoluble substrates in organic solvents, a new type of immobilized enzyme, a lipid-lipase aggregate, was developed. In order to prepare various kinds of lipid-lipase aggregates, 27 kinds of dialkyl ether-type phospholipid analogues were newly synthesized and used for the preparation of aggregates with lipase. Thus obtained lipid-lipase aggregates were found to catalyze the enantioselective hydrolysis of the (+)-α-acyloxy ester 2 much more efficiently than lipase immobilized with synthetic prepolymer (ENTP-4000) in water-saturated isopropyl ether. Namely, the reaction time became much shorter (2 to 3 d for completion as compared with 21 d) and the chemical and optical yields of the reaction products were found to be high.
