6949-91-3

Usage

Chemical class

Dihydroquinoline derivative

Structural features

Contains a benzoyl group
Contains a carboxamide group

Potential applications

Pharmaceutical industry
Anti-tumor properties
Anti-inflammatory properties

Research and development

Suitable for developing new drugs targeting cancer and inflammatory diseases

Safety and handling

Must be handled and stored according to proper safety protocols and regulations

Upstream product

• 13721-17-0 1-benzoyl-1,2-dihydro-quinoline-2-carbonitrile 
• 91-22-5 quinoline 
• 98-88-4 benzoyl chloride 

Downstream Products

• 2172-71-6 1-benzoyl-1,2-dihydroquinoline-2-carboxylic acid methyl ester 

Relevant academic research and scientific papers

Remote control of the C-3-C-4 double-bond epoxidation of a chiral 1,2-dihydroquinoline: Application to the synthesis of (-)-(r)-sumanirole (PNU-95666E)

A twelve-step synthesis of (-)-(R)-sumanirole starting from quinoline is described. The first synthetic approach, using a chiral Reissert adduct, was too problematic to be pursued further. In the second successful approach, the authors took advantage of the stereoselective epoxidation of a 1,2-dihydroquinoline bearing an Evans' chiral auxiliary at N-1. A twelve-step synthesis of (-)-(R)-sumanirole hydrochloride has been developed from quinoline. In the successful approach, the key reaction is a diastereoselective epoxidation of the C-3-C-4 double bond of a 1,2-dihydroquinoline bearing a chiral oxazolidinone-derived auxiliary at N-1.

2-substituted-1-acyl-1,2-dihydroquinoline derivatives

This invention relates to the use of 2-substituted-1-acyl-1,2-dihydroquinoline derivatives to increase high density lipoprotein cholesterol (HDL-C) concentration and as therapeutic compositions for treating atherosclerotic conditions such as dyslipoprotei