69491-45-8

Upstream product

• 77287-34-4 formamide 
• 586-37-8 1-(3-Methoxyphenyl)ethanone 
• 122806-25-1 1-(3-methoxy-phenyl)-ethanone oxime 
• 896868-57-8 1-(3-methoxyphenyl)ethanone O-acetyl oxime 
• 149-73-5 trimethyl orthoformate 
• 140118-17-8 4-chloro-6-(3-methoxyphenyl)pyrimidine 
• 4774-33-8 tris(formylamino)methane 
• 17758-33-7 3-methyl-5-nitro-4(3H)-pyrimidinone 

Downstream Products

• 883822-93-3 C₂₄H₁₉N₃O₆ 
• 883822-88-6 C₂₄H₁₉N₃O₆ 

Relevant academic research and scientific papers

Catalyst free synthesis of mono- and disubstituted pyrimidines from O-acyl oximes

Transition-metal or iodine catalyzed transformations of O-acyl oximes to various N-heterocycles are well established. Herein, we report a catalyst free, oxime carboxylate based, three-component condensation method to access mono- and disubstituted pyrimidines. A broad range of substituted pyrimidines were prepared in moderate to excellent yields. Control experiments reveal that in situ generated formamidine is the key intermediate.

Synthesis of 4-aryl and unsymmetrical 4,6-diarylpyrimidines by the Suzuki-Miyaura cross-coupling reaction

A two-step procedure for the synthesis of 4-arylpyrimidines from inexpensive 4,6-dichloropyrimidine via a Suzuki-Miyaura/hydrodechlorination reaction sequence is described. The reaction resulted in the predominant formation of mono-arylated product. The c

Efficient one-pot, three-component synthesis of a library of pyrrolo[1,2-c]pyrimidine derivatives

Herein is reported a simple and efficient one-pot three-component synthesis of pyrrolo[1,2-c]pyrimidine derivatives starting from various substituted pyrimidines, 2-bromoacetophenones, and electron deficient alkynes in epoxides acting both as reaction medium and HBr scavanger. This method proved to be very lucrative and avoids formation of ylide inactivation products. The synthesis represents an environmentally benign alternative to classical methods. The new library of compounds was briefly characterized regarding the improved Lipinski rule to asses the potential drug-likeness of the compounds. The majority of compounds are statisfing the Lipinski rule.

Synthesis of pyrimidines from ketones using microwave irradiation

A simple, high yielding synthesis of pyrimidines from ketones in the presence of HMDS and formamide is described. Under microwave irradiation, heteroaromatic, aryl, aliphatic, and cyclic ketones cyclized to give pyrimidines in good yields.

Novel synthesis of bihetaryl compounds

The ring transformation of nitropyrimidinone 1 with acetophenone derivatives 2 affords two kinds of azaheterocyclic compounds, 4-phenylpyrimidines 3 and 3-nitro-6-phenyl-2-pyridones 4. On the basis of the relationship between electronic properties of the substituent and ratios of products, a plausible reaction mechanism is provided. Furthermore, the present reaction could be applied to heterocyclic ketones giving bihetaryl compounds.