695-85-2

Basic information

• Product Name: Pyrimidine, 4-chloro-5-methoxy- (6CI,7CI,8CI,9CI)
• Synonyms: Pyrimidine, 4-chloro-5-methoxy- (6CI,7CI,8CI,9CI);4-Chloro-5-methoxypyrimidine
• CAS NO: 695-85-2
• Molecular Formula: C5H5ClN2O
• Molecular Weight: 144.561
• Product Categories: PYRIMIDINE
• Mol File: 695-85-2.mol
• Article Data: 7

Chemical Properties

• Melting Point: 63-64℃
• Boiling Point: 221.9ºC at 760 mmHg
• Flash Point: 88ºC
• Appearance: /
• Density: 1.292g/cm3
• Vapor Pressure: 0.155mmHg at 25°C
• Refractive Index: 1.52
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 0.17±0.16(Predicted)
• CAS DataBase Reference: Pyrimidine, 4-chloro-5-methoxy- (6CI,7CI,8CI,9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrimidine, 4-chloro-5-methoxy- (6CI,7CI,8CI,9CI)(695-85-2)
• EPA Substance Registry System: Pyrimidine, 4-chloro-5-methoxy- (6CI,7CI,8CI,9CI)(695-85-2)

Safety Data

• Hazardous Substances Data: 695-85-2(Hazardous Substances Data)

Usage

General Description

Pyrimidine, 4-chloro-5-methoxy- (6CI,7CI,8CI,9CI), also known as 4-Chloro-5-methoxypyrimidine, is a chemical compound with the molecular formula C5H5ClN2O. It is a derivative of the heterocyclic compound pyrimidine, which is commonly found in nucleic acids such as DNA and RNA. This particular derivative has a chlorine atom at the 4th position of the pyrimidine ring and a methoxy group at the 5th position. It is used in the synthesis of pharmaceuticals and agrochemicals, and also as an intermediate in organic synthesis. It is important to handle this chemical with care, as it may pose health risks if not handled properly.

InChI:InChI=1/C5H5ClN2O/c1-9-4-2-7-3-8-5(4)6/h2-3H,1H3

Upstream product

• 19646-07-2 2,4-dichloro-5-methoxypyrimidine 
• 695-87-4 5-methoxypyrimidin-4-ol 
• 695-87-4 5-methoxy-4(3H)-pyrimidinone 

Downstream Products

• 1383663-92-0 4-(4-t-butylbenzyloxy)-5-methoxypyrimidine 
• 695-86-3 amino-4 methoxy-5 pyrimidine 
• 141071-88-7 4-(5-Methoxy-4-pyrimidinyl)-2-methylpiperazine 
• 151140-96-4 avitriptan 
• 141071-86-5 5-methoxy-4-piperazin-1-yl-pyrimidine 

Relevant articles and documents

PYRIMIDINE AND TRIAZINE DERIVATIVES AND THEIR USE AS AXL INHIBITORS

Compounds of the general formula(I): (I) processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds.

NaBH4-TMEDA and a palladium catalyst as efficient regio- and chemoselective system for the hydrodehalogenation of halogenated heterocycles

The pair NaBH4-TMEDA as hydride source and a palladium catalyst in THF prove to be an efficient system for the hydrodehalogenation of halogenated heterocycles with one or more heteroatoms. In general, Pd(OAc) 2-PPh3 rapidly hydrodehalogenates reactive halo-heterocycles such as bromo-pyridines, -quinolines, -thiophenes, -indoles, -imidazoles, etc., at room temperature in very good yields, whereas in most cases PdCl2(dppf) reduces less reactive halides such as chloro-pyridines, -quinolines, -pyrimidines and bromo-indoles, -benzofurans, etc. Moreover, PdCl2(tbpf) shows to be even more active removing the 2- and 5-chlorine from both thiophene and thiazole rings. The reaction conditions tolerate various functional groups, allowing highly chemoselective reactions in the presence of halide, ester, alkyne, alkene and nitrile substituents. Moreover, with a proper selection of the catalyst it is also possible to obtain a good control in the regioselective hydrodehalogenation of a variety of polyhalogenated substrates.

ARYL-ALKYNE COMPOUNDS AS HERBICIDES

Compounds of formula (I) wherein Q is a group formula (II), (III); Z is=N-, formula (IV) or =C(R2)-; n is 0, 1, 2 or 3; R3 or R4 are each independently of the other hydrogen, alogen, -CN, C1-C4alkyl o