695-86-3

Usage

Uses

Used in Pharmaceutical Research and Drug Development:
4-Pyrimidinamine, 5-methoxy(9CI) is used as a potential anti-cancer agent for its ability to inhibit the growth of cancer cells. It is being studied for its potential to target and disrupt the mechanisms that allow cancer cells to proliferate and survive, thereby offering a new avenue for cancer treatment.
Additionally, 4-Pyrimidinamine, 5-methoxy(9CI) is used as a potential anti-viral agent, with its biological activity being investigated for its capacity to block viral replication. This could be instrumental in developing new antiviral therapies, particularly for viruses that are resistant to existing treatments.
Further research is necessary to fully understand the mechanisms of action of 4-Pyrimidinamine, 5-methoxy(9CI) and to explore its potential therapeutic applications in various medical fields. This includes assessing its efficacy, safety, and optimal delivery methods to maximize its benefits in treating cancer and viral infections.

InChI:InChI=1/C5H7N3O/c1-9-4-2-7-3-8-5(4)6/h2-3H,1H3,(H2,6,7,8)

Upstream product

• 101012-11-7 5-bromo-2,6-dichloropyrimidin-4-amine 
• 31458-33-0 5-methoxypyrimidine 
• 180284-27-9 8-Methoxy-tetrazolo[1,5-c]pyrimidine 
• 695-85-2 4-chloro-5-methoxy-pyrimidine 
• 5018-41-7 6-chloro-5-methoxypyrimidine-4-amine 
• 695-87-4 5-methoxypyrimidin-4-ol 

Downstream Products

• 52601-89-5 4-amino-5-hydroxy-pyrimidine 

Relevant academic research and scientific papers

PYRIMIDINE AND TRIAZINE DERIVATIVES AND THEIR USE AS AXL INHIBITORS

Compounds of the general formula(I): (I) processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds.

Development of a Scalable Synthesis of 4-Aminopyrimidin-5-ol, a Versatile Intermediate

A robust process for the preparation of multigram quantities of 4-aminopyrimidin-5-ol (5) in good yield from an inexpensive and readily available pyrimidine starting material is described. An initial evaluation of the reported literature route for this material utilizing a de novo pyrimidine synthesis provided safety concerns over the scalability of several intermediates. In addition, a number of steps proceeded in mediocre yield, and involved chromatographic separations for the desired products. The newly developed route mitigates the safety concerns, reduces the number of steps from five to three, avoids column chromatography, leads to an 8-fold improvement in yield, and utilizes reagents, which are recognized to be more environmentally benign.

Chiral 3-(4,5-dihydrooxazol-2-yl)phenyl alkylcarbamates as novel FAAH inhibitors: Insight into FAAH enantioselectivity by molecular docking and interaction fields

Fatty acid amide hydrolase (FAAH) and monoglyceride lipase (MGL) are the main enzymes responsible for the hydrolysis of endogenous cannabinoids N-arachidonoylethanolamide (AEA) and 2-arachidonoylglycerol (2-AG), respectively. Phenyl alkylcarbamates are FA

A new route to aminodiazines via metalation reaction. Synthesis of an aza analogue of Nevirapine: Diazines XV

A new route to aminodiazines is reported, the ortho-directed lithiation of diazines is used, followed by reaction with tosyl azide as an electrophile. The reduction of the azido or tetrazolo compounds obtained was achieved and led to the expected amines. This methodology has allowed the synthesis of new aminodiazines and an improvement in the yield of various aminodiazines previously described. This reaction was used for the preparation of an aza analogue of Nevirapine.