69500-29-4

Usage

Uses

Used in Plastic Industry:
Bis(o-isopropylphenyl) Phenyl Phosphate is used as a plasticizer for polyvinyl chloride (PVC) to improve its flexibility, workability, and durability. Its incorporation into PVC helps to reduce the brittleness and stiffness of the material, making it more suitable for a wide range of applications, such as pipes, cables, and other plastic products.
Used in Flame Retardant Industry:
Bis(o-isopropylphenyl) Phenyl Phosphate is also used as a flame retardant, particularly in the plastics and textiles industries. Its addition to materials can significantly reduce the risk of ignition and slow down the spread of fire, providing an essential safety feature for various products, including electronic casings, upholstery, and other flammable materials.
Used in Pharmaceutical Research:
Studies have shown that Bis(o-isopropylphenyl) Phenyl Phosphate inhibits the human androgen receptor, which plays a crucial role in the development and progression of certain types of cancer, such as prostate cancer. This property makes it a potential candidate for further research and development in the field of pharmaceuticals, particularly for the treatment of androgen-dependent cancers.

Upstream product

• 88-69-7 2-(1-methylethyl)phenol 
• 770-12-7 O-phenyl phosphorodichloridate 

Relevant academic research and scientific papers

Effects of triaryl phosphates on mouse and human nuclear receptors

The constitutively active receptor (CAR) is a crucial regulator of genes encoding for enzymes active in drug/steroid oxidation, conjugation, and transport. In our attempt to isolate the endogenous inhibitory ligand(s) for the mouse CAR, we found surprisingly that the inhibitory activity was associated with di- and tri-isopropylated phenyl phosphates that were present in livers of untreated mice. Trans-activation experiments in mammalian cells with synthetic compounds verified that mouse CAR was inhibited by various isopropylated phenyl phosphates (40-80%). Such triaryl phosphates are widely used as fire retardants, lubricants, and plasticizers, and some of them are known to disturb reproduction by currently unknown mechanisms. Equipped with the finding that these compounds could interact with mouse CAR, we proceeded to determine their functional effects on other nuclear receptors. Human CAR and pregnane X receptor (PXR) were variably activated (2-5-fold) by triaryl phosphates while mouse PXR, peroxisome proliferator-activated receptor-α, and vitamin D receptor were refractory. Among steroid hormone receptors, the human androgen receptor was inhibited by triphenyl phosphate and di-ortho-isopropylated phenyl phosphate (40-50%) and activated by di- and tri-para-substituted phenyl phosphates (2-fold). Our results add to the list of CAR and PXR activators and suggest steroid-dependent biological pathways that may contribute to the reproductive effects of triaryl phosphates.