69502-32-5

Usage

Type of compound

organic compound, sulfonate ester

Structure

Contains a 4-methylbenzenesulfonate group attached to a tetrahydro-2H-pyran-2-yl moiety through an ether linkage

Uses

Commonly used as a reagent in organic synthesis, as a building block in the preparation of pharmaceuticals, agrochemicals, and other fine chemicals, as a solubilizing agent, and as a surfactant in various industrial applications.

Importance

Synthetic versatility and functional groups allow for a wide range of uses and play an important role in the development of new chemical compounds.

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 
• 2163-11-3 2-(2-tetrahydropyran-2-yloxyethanoxy)ethanol 
• 108-88-3 toluene 
• 110-87-2 3,4-dihydro-2H-pyran 
• 118591-58-5 5-tosyloxy-3-oxapentanol 

Downstream Products

• 106658-67-7 C₂₈H₄₆O₁₀ 

Relevant academic research and scientific papers

ETHER COMPOUND AND DERIVATIVE THEREOF AND LUBRICANT BASE OIL

PROBLEM TO BE SOLVED: To provide an ether compound and an ether derivative having low viscosity, having excellent flowability even at low temperatures, and having high viscosity indexes and a lubricant base oil containing the compound. SOLUTION: The present disclosure provides an ether compound or an ether derivative represented by formula (I) (where, n is 1-20, R1 is hydrogen or an acyl group represented by formula (II). R2 is a C1-35 hydrocarbon group). SELECTED DRAWING: None COPYRIGHT: (C)2021,JPOandINPIT

MODULATORS OF PROTEOLYSIS AND ASSOCIATED METHODS OF USE

The present disclosure relates to bifunctional compounds, which find utility as modulators of Kirsten rat sarcoma protein (target protein). In particular, the present disclosure is directed to bifunctional compounds, which contain on one end a Von Hippel-Lindau, cereblon, Inhibitors of Apotosis Proteins or mouse double-minute homolog 2 ligand which binds to the respective E3 ubiquitin ligase and on the other end a moiety which binds the target protein, such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of target protein. The present disclosure exhibits a broad range of pharmacological activities associated with degradation/inhibition of target protein. Diseases or disorders that result from aggregation, accumulation, and/or overactivation of the target protein are treated or prevented with compounds and compositions of the present disclosure.

SULFINYLPHENYL OR SULFONIMIDOYLPHENYL BENZAZEPINES

This invention relates to novel sulfinylphenyl or sulfonimidoylphenyl benzazepine compounds of the formula (I) wherein X and R1 to R6 are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. These compounds are TLR agonists and may therefore be useful as medicaments for the treatment of diseases such as cancer, autoimmune diseases, inflammation, sepsis, allergy, asthma, graft rejection, graft-versus-host disease, immunodeficiencies, and infectious diseases.

Preparation of 7-methoxy tacrine dimer analogs and their in vitro/in silico evaluation as potential cholinesterase inhibitors

Novel types of symmetric bis-7-methoxytacrines connected by oligoethyleneoxy chains 3-5 and nonsymmetric monomeric 7-methoxytacrines containing hydroxyl-terminated oligoethyleneoxy chains 6-8 were prepared, and their in vitro/in silico effects on human recombinant AChE (hAChE) and human plasmatic butyrylcholinesterase (hBChE) were compared, with 7-MEOTA (2) as the standard compound. The symmetric bis-7-MEOTA derivatives 3-5 showed hAChE inhibition similar to that of 2. On the other hand, their effects on hBChE revealed an increasing inhibition trend when the oligoethyleneoxy units between the two 7-MEOTA moieties became longer. Accordingly, compounds 4 and 5 showed better selectivity towards hBChE. The most effective in the inhibition hAChE and hBChE was compound 8 with the longest oligoethyleneglycol chain, whereas compounds 6 and 7 resulted in similar IC50 values. A molecular modeling study using substrates 5 and 8 showed a possible binding conformation and protein-ligand interaction between the substrates and AChE/BChE.

A 2,2'-bipyridyl-bridged tetrathiafulvalene-quinone dyad: Intramolecular electron-transfer promoted by metal ions

A 2,2'-bipyridyl-bridged tetrathiafulvalene (TTF)-quinone dyad (1) was synthesized and characterized. Both absorption and ESR spectroscopic studies clearly indicate that electron transfer occurs from TTF to the quinone unit for dyad 1 in the presence of m