69504-17-2

Upstream product

• 65109-15-1 2'-O-t-Butyldimethylsilyl-5'-O-monomethoxytrityl-N⁶-benzoyluridin 
• 87418-87-9 2',3'-bis-O-(tert-butyldimethylsilyl)uridine 
• 60010-51-7 β,β,β-trichloroethyl phosphorodichloridite 
• 77245-03-5 C₅₈H₈₂Cl₃N₄O₁₄PSi₃ 

Downstream Products

• 2415-43-2 uridylyl-3',5'-uridine 

Relevant academic research and scientific papers

The synthesis of oligoribonucleotides VI. The synthesis of a hexadecamer by a block condensation approach

The synthesis of the 5'-monomethoxytrityl-2'-tert-butyldimethylsilyl-3'-levulinylribonucleosides 4 of the four major bases involved in the phosphite procedure for the synthesis of oligoribonucleotides is described along with the 2',3'-isomeric derivatives

The chemical synthesis of oligoribonucleotides. IX. A comparison of protecting groups in the dichloridite procedure

A series of phosphorodichloridites has been prepared incorporating the most commonly used phosphate protecting groups in oligonucleotide synthesis.The groups incude trichloroethyl, tribromoethyl, cyanoethyl, benzyl, methyl, p-chlorophenyl, and nitrophenetyl.The trichloroethyl and the nitrophenethyl appear to be the most stable groups while the cyanoethyl and methyl offer specific advantages.The benzyl and p-chlorophenyl groups are subject to limitations on their utility.Condensations can be carried out in a range of solvents incuding THF, pyridine, and DMF and at temperatures from -78 deg C to 20 deg C with a slight drop in yield with increasing temperature, at least for dinucleotide condensations.