6951-40-2

Usage

Uses

Used in Pharmaceutical Research and Drug Development:
[(4-chlorobenzyl)amino](oxo)acetic acid is used as a building block for the synthesis of biologically active compounds, contributing to the development of new pharmaceuticals. Its unique chemical structure and reactivity make it a valuable component in creating novel drugs with potential therapeutic applications.
Used in Organic Synthesis:
In the field of organic synthesis, [(4-chlorobenzyl)amino](oxo)acetic acid serves as a versatile intermediate for creating a range of chemical products. Its distinct functional groups allow for further reactions and modifications, expanding the scope of possible applications in various industries.
Used in Medicinal Chemistry:
[(4-chlorobenzyl)amino](oxo)acetic acid is employed in medicinal chemistry for the design and synthesis of new drug candidates. Its incorporation into molecular structures can potentially enhance the pharmacological properties of these candidates, leading to improved treatments for various diseases and conditions.

Upstream product

• 4755-77-5 Ethyl oxalyl chloride 
• 104-86-9 4-chlorobenzylamine 
• 6951-43-5 N-Ethoxyoxalyl-4-chlor-benzylamin 

Relevant academic research and scientific papers

Urethanes synthesis from oxamic acids under electrochemical conditions

Urethane synthesis via oxidative decarboxylation of oxamic acids under mild electrochemical conditions is reported. This simple phosgene-free route to urethanes involves an in situ generation of isocyanates by anodic oxidation of oxamic acids in an alcoholic medium. The reaction is applicable to a wide range of oxamic acids, including chiral ones, and alcohols furnishing the desired urethanes in a one-pot process without the use of a chemical oxidant.

Visible-light mediated carbamoyl radical addition to heteroarenes

The generation of carbamoyl radicals, followed by their addition to heteroarenes, was performed under mild conditions through a metal-free photocatalyzed decarboxylation of oxamic acids. The process has been applied to the carbamoylation of heteroaromatic bases using α-aminoacid-derived oxamic acids, leading to the corresponding amides without racemization.

Visible-light photocatalyzed oxidative decarboxylation of oxamic acids: a green route to urethanes and ureas

A sustainable metal-free route to urethanes and ureas based on a photocatalyzed oxidative decarboxylation of oxamic acids is described. The reaction includes in situ generation of an isocyanate from the oxamic acid, using an organic dye as a photocatalyst, a hypervalent iodine reagent as an oxidant and a light source, which trigger the free-radical decarboxylation. This protocol successfully avoids the isolation, purification and storage of carcinogenic isocyanates and allows elaboration of urethanes and ureas in a one-pot process from commercially available sources.