695172-01-1

Basic information

• Product Name: diphenyl α-N(benzyloxycarbonyl)amino-(4-(di-Bocguanidiniumphenyl))methanephosphonate
• Synonyms: diphenyl α-N(benzyloxycarbonyl)amino-(4-(di-Bocguanidiniumphenyl))methanephosphonate
• CAS NO: 695172-01-1
• Molecular Weight: 730.755
• Mol File: 695172-01-1.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: diphenyl α-N(benzyloxycarbonyl)amino-(4-(di-Bocguanidiniumphenyl))methanephosphonate(CAS DataBase Reference)
• NIST Chemistry Reference: diphenyl α-N(benzyloxycarbonyl)amino-(4-(di-Bocguanidiniumphenyl))methanephosphonate(695172-01-1)
• EPA Substance Registry System: diphenyl α-N(benzyloxycarbonyl)amino-(4-(di-Bocguanidiniumphenyl))methanephosphonate(695172-01-1)

Safety Data

• Hazardous Substances Data: 695172-01-1(Hazardous Substances Data)

Upstream product

• 785827-88-5 diphenyl α-N-(benzyloxycarbonyl)amino(4-aminophenyl)methanephosphonate 
• 556-18-3 4-aminobenzaldehyde 
• 152120-54-2 N,N'-bis( tert-butoxycarbonyl)-1H-pyrazole-1-carboxamidine 
• 152904-82-0 <<<<(4-nitrophenyl)-2-benzyl>oxy>carbonyl>amino>methylphosphonate 
• 555-16-8 4-nitrobenzaldehdye 
• 621-84-1 O-benzyl carbamate 
• 101-02-0 triphenyl phosphite 
• 695171-94-9 diphenyl {[(benzyloxy)carbonyl]amino}[4-(tert-butoxycarbonyl)aminophenyl]methylphosphonate 
• 144072-29-7 tert-butyl N-[4-(hydroxymethyl)phenyl]carbamate 
• 144072-30-0 4-((tert-butoxycarbonyl)amino)benzaldehyde 
• 623-04-1 4-aminobenzenemethanol 
• 152120-54-2 (Z)-tert-butyl (((tert-butoxycarbonyl)imino)(1H-pyrazol-1-yl)methyl)carbamate 

Downstream Products

• 1450636-21-1 diphenyl α-N-(propiolamido)(4-guanidiniumphenyl)methanephosphonate 
• 695172-15-7 diphenyl ((N-benzyloxycarbonyl-O-tert-butyl-D-seryl)-L-alanyl)amino-(4-(N,N'-bis(tert-butyloxycarbonyl)guanyl)phenyl)methanephosphonate 
• 695172-08-8 diphenyl (N-benzyloxycarbonyl-L-alanyl)amino-(4-(N,N'-bis(tert-butyloxycarbonyl)guanyl)phenyl)methanephosphonate 
• 785827-90-9 C₃₀H₃₇N₄O₇P 

Relevant articles and documents

The first potent diphenyl phosphonate KLK4 inhibitors with unexpected binding kinetics

KLK4 is a serine protease from the kallikrein family that is involved in cancer progression. The diphenyl phosphonate warhead is intended to bind irreversibly with serine proteases, but unexpectedly, very potent KLK4 diphenyl phosphonate inhibitors were d

Tuning activity-based probe selectivity for serine proteases by on-resin 'click' construction of peptide diphenyl phosphonates

Activity-based probes (ABPs) are powerful tools for functional proteomics studies. Their selectivity can be influenced by modification of a recognition element that interacts with pockets near the active site. For serine proteases there are a limited numb

Development of Irreversible Diphenyl Phosphonate Inhibitors for Urokinase Plasminogen Activator

In this letter we report the synthesis and biochemical evaluation of selective, irreversible diphenyl phosphonate inhibitors for urokinase plasminogen activator (uPA). A diphenyl phosphonate group was introduced on the substratelike peptide Z-D-Ser-Ala-Arg, and modification of the guanidine side chain was investigated. A guanylated benzyl group appeared the most promising side chain modification. A kapp value in the 103 M -1 s-1 range for uPA was obtained, together with a selectivity index higher than 240 toward other trypsin-like proteases such as tPA, thrombin, plasmin, and FXa.