6952-53-0

Usage

Uses

Used in Pharmaceutical Industry:
2-METHYLPROYL 2-PYRIDYL KETONE is used as a building block in organic synthesis for the development of new pharmaceutical compounds. Its unique structure allows it to be a valuable component in the creation of various drugs.
Used in Agrochemical Industry:
In the agrochemical industry, 2-METHYLPROYL 2-PYRIDYL KETONE is used as a precursor in the synthesis of agrochemicals, contributing to the development of effective pesticides and other agricultural products.
Used as a Chiral Auxiliary:
2-METHYLPROYL 2-PYRIDYL KETONE is used as a chiral auxiliary in asymmetric synthesis, playing a crucial role in the production of enantiomerically pure compounds, which are essential in various chemical and pharmaceutical applications.
Used as a Ligand in Transition Metal Catalysis:
2-METHYLPROYL 2-PYRIDYL KETONE is also utilized as a ligand in transition metal catalysis, facilitating a range of chemical reactions that are vital in the synthesis of complex organic molecules.
Used in Medicinal Research:
2-METHYLPROYL 2-PYRIDYL KETONE is studied for its potential medicinal properties, such as its anticancer effects, making it a candidate for further research and development in the field of oncology.
Used in Anti-Inflammatory Research:
Additionally, it is explored for its anti-inflammatory properties, indicating its potential use in the development of treatments for various inflammatory conditions.

InChI:InChI=1/C10H13NO/c1-8(2)7-10(12)9-5-3-4-6-11-9/h3-6,8H,7H2,1-2H3

Upstream product

• 503-74-2 3-methylbutyric acid 
• 109-04-6 2-bromo-pyridine 
• 147356-77-2 N-methoxy-N,3-dimethylbutanamide 
• 100-70-9 2-Cyanopyridine 
• 926-62-5 isobutylmagnesium bromide 

Downstream Products

• 1452507-31-1 2-hydroxy-4,5-bis(4-hydroxyphenyl)-2-isobutyl-1H-pyrrol-3(2H)-one 
• 68141-26-4 6-(2-methylpropyl)quinoline 
• 7661-51-0 4-isobutylquinoline 
• 1263198-29-3 tert-butyl (3R,5S)-3-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]-5-{[(1R)-3-methyl-1-(2-pyridyl)butyl]carbamoyl}piperidine-1-carboxylate 
• 1263197-17-6 C₂₈H₃₈ClN₅O₂ 
• 825647-69-6 3-methyl-1-(pyridin-2-yl)butan-1-amine 
• 127142-27-2 2-(3-methylbutyryl)pyridine 5-<(2-chloroanilino)thiocarbonyl>thiocarbonohydrazone 
• 1122-62-9 2-acetylpyridine 
• 138835-93-5 2,2-Dimethyl-1-pyridin-2-yl-cyclopropanol 
• 138835-94-6 3-Methyl-1-pyridin-2-yl-cyclobutanol 
• 138835-95-7 3-Methyl-1-pyridin-2-yl-cyclobutanol 

Relevant academic research and scientific papers

Synthesis of new cyclazines and 4,5-diaryl-1 H -pyrrol-3(2 H)-one units in discoipyrroles from indolizinone-DMAD cycloadducts

The reaction of indolizinones with dimethyl acetylenedicarboxylate gave direct access to 3′,8a-dihydrocyclopenta[hi]indolizin-8a-ol and 1H-pyrrol-3(2H)-one in good yields. The former skeleton is a precursor to cyclazines with nitrogen on the periphery, a hitherto un-accessed 10-π system. Their formation involves initial [4 + 2] or [8 + 2] modes of cycloadditions; the retro-Diels Alder reaction of the [4 + 2] cycloadduct leads to 1H-pyrrol-3(2H)-one, whereas [8 + 2] addition followed by π-reorganization leads to the azatricyle. Analysis of substituent effects on product distribution showed that electron donating groups on the C3-aryl ring promote the formation of the azatricycle preponderantly. Treatment of one of these azatricycles (3c) with HBF4 led to the formation of the corresponding 10e-aromatic species which was detected by NMR spectroscopy. In addition, formation of the 1H-pyrrol-3(2H)-one skeleton through the normal retro-Diels Alder pathway was employed in the total synthesis of Discoipyrrole C, which is a new lead against lung cancer.

Pd-Catalyzed Alkylation of (Iso)quinolines and Arenes: 2-Acylpyridine Compounds as Alkylation Reagents

The first Pd-catalyzed alkylation of (iso)quinolines and arenes is reported. The readily available and bench-stable 2-acylpyridine compounds were used as an alkylation reagent to form the structurally versatile alkylated (iso)quinolines and arenes. The method affords a convenient pathway for the introduction of alkyl groups into organic molecules.

SUBSTITUTED AMINOTHIAZOLES AS INHIBITORS OF CANCERS, INCLUDING HEPATOCELLULAR CARCINOMA, AND AS INHIBITORS OF HEPATITIS VIRUS REPLICATION

Pharmaceutical compositions of the invention are presented which comprise substiuted aminothiazoles derivatives. The substiuted aminothiazoles derivatives have a disease-modifying action in the treatment of diseases associated with unregulated cell growth. Such diseases include cancers such as hepatocellular carcinoma, and viral infections from a hepatitis virus.

NOVEL 2,4,6-TRI-SUBSTITUTED HETEROCYCLES AND USES THEREOF

Compounds of formula (I) and (II); their pharmaceutical compositions and methods of use for the treatment of neurological disorders related to amyloid ? protein production such as Alzheimer's disease.

Triplet states mediating hydrogen abstraction in 4-acylpyrimidines, 2-acylpyridines, 2-acylpyrazines, and 3-acylpyridazines

Irradiation of 9 leads to hydrogen abstraction by N(1) and fragmentation to 8 from a triplet with ET ～78 kcal/mol. Irradiation of 2-acylpyridines (10) leads to abstraction by both nitrogen and oxygen (cf. eq 4), with the same Stern-Volmer kqτ for the two processes. Irradiation of 2-acylpyrazines (11) can lead to abstraction by either nitrogen (φ27 0.77 from 11b) or oxygen (φ11a 0.95 from 11f)- 3-Acylpyridazine 12d is unreactive on direct irradiation or triplet sensitization with sensitizer ET ～70 kcal/mol; it furnishes a small amount of 12a on sensitization by acetone. Ketone 18 is recovered unchanged from irradiation under all conditions used with 12d. These observations suggest a correlation between the photochemistry of each of these compounds and the energy of the nπ* triplet of the heteroaromatic ring. The nature of the excited state(s) responsible for hydrogen abstraction by nitrogen and oxygen in these ketones is discussed.