69520-85-0Relevant articles and documents
Synthesis of 3,7-disubstituted 10-methylphenothiazines
Ebdrup, S?ren
, p. 1107 - 1109 (2007/10/03)
Lithiation at the C-3 and C-7 positions of N-methylphenothiazine (1) can be achieved by halogen metal exchange reaction starting from 3,7-dibromo-10-methylphenothiazine (2). Reaction of the lithiated species with carbon, sulfur and silicon electrophiles results in new 3,7-disubstituted 10-methylphenothiazines 4a-g. The described procedure gives high yield and an easy excess to important enzyme mediators.