695211-56-4Relevant academic research and scientific papers
An efficient synthesis of 5-substituted 1H-tetrazoles via B(C 6F5)3 catalyzed [3+2] cycloaddition of nitriles and sodium azide
Prajapti, Santosh Kumar,Nagarsenkar, Atulya,Babu, Bathini Nagendra
, p. 3507 - 3510 (2014/06/10)
A simple and efficient protocol is developed for the synthesis of 5-substituted 1H-tetrazole derivatives from various nitriles and sodium azide (NaN3) via [3+2] cycloaddition reaction using B(C6F 5)3 as a catalyst. The present synthetic method displayed significant advantages such as low catalyst loading, mild reaction conditions, low toxicity, easy work-up, high yields, and compatibility with other functional groups.
