695216-00-3

Upstream product

• 124-63-0 methanesulfonyl chloride 
• 23218-93-1 3-amino-5-nitro-benzoic acid methyl ester 

Downstream Products

• 868286-95-7 C₃₃H₃₉FN₆O₅S 
• 868286-93-5 C₃₃H₃₈FN₅O₆S 
• 868287-50-7 3-(N-methyl-N-(methylsulfonyl)amino)-5-(3-((R)-2-tert-butoxycarbonylamino-1-phenylpropan-2-yl)isoxazol-5-yl)-N-((R)-1-(4-fluorophenyl)ethyl)benzamide 
• 868287-86-9 C₃₀H₃₀FN₅O₄S 
• 868287-48-3 3-(N-methyl-N-(methylsulfonyl)amino)-N-((R)-1-(4-fluorophenyl)ethyl)-5-(2-(trimethylsilyl)ethynyl)benzamide 
• 868287-82-5 C₂₃H₂₃FN₂O₅S 
• 868287-80-3 C₂₃H₂₅FN₂O₅S 
• 868286-37-7 3-[amino(hydroxyimino)methyl]-N-[(1R)-1-(4-fluorophenyl)ethyl]-5-[methyl(methylsulfonyl)amino]benzamide 
• 868286-77-5 N-[(1R)-1-(4-fluorophenyl)ethyl]-3-(5-formyl-2-furyl)-5-[methyl(methylsulfonyl)amino]benzamide 
• 1048666-17-6 ethyl-3-({[(1R)-1-(4-fluorophenyl)ethyl]amino}carbonyl)-5-[methyl(methylsulfonyl)amino]benzenecarboximidoate 
• 868287-49-4 3-(N-methyl-N-(methylsulfonyl)amino)-5-ethynyl-N-((R)-1-(4-fluorophenyl)ethyl)benzamide 
• 868286-36-6 3-cyano-N-[(1R)-1-(4-fluorophenyl)ethyl]-5-[methyl(methylsulfonyl)amino]benzamide 
• 868286-34-4 C₁₇H₁₈FN₃O₅S 
• 868286-35-5 3-bromo-N-[(1R)-1-(4-fluorophenyl)ethyl]-5-[methyl(methylsulfonyl)amino]benzamide 

Relevant academic research and scientific papers

IMIDAZOPYRIDINE COMPOUNDS

Compounds, pharmaceutical compositions, kits and methods are provided for use with glucokinase that comprise a compound selected from the group consisting of formula (I) wherein the variables are as defined herein.

Pteridinone derivatives as PI3-kinases inhibitors

New compounds of formula 1 are provided which by virtue of their pharmaceutical activity as PI3-kinase modulators may be used in the therapeutic field for the treatment of inflammatory or allergic diseases. Examples of these include inflammatory and allergic respiratory complaints, inflammatory diseases of the gastro-intestinal tract and motor apparatus, inflammatory and allergic skin diseases, inflammatory eye diseases, diseases of the nasal mucosa, inflammatory or allergic conditions involving autoimmune reactions or inflammations of the kidney.

β SECRETASE INHIBITOR

Disclosed is a compound represented by the formula (1) below which is useful as a drug for treating Alzheimer's disease, or a pharmaceutically acceptable salt thereof. (1) [In the formula, R1 represents a group represented by the following formula (2): (2) (wherein X represents a nitrogen atom or a group expressed as C(R5); Y represents a nitrogen atom or a group expressed as C(R6); and R5 and R6 independently represent a hydrogen atom or the like) or the like; m represents an integer of 1-6; L1 represents a single bond or the like; R2 represents a hydrogen atom, a substituted or unsubstituted alkyl group or the like; R3 represents a hydrogen atom or the like; L2 represents a single bond or the like; and R4 represents a hydrogen atom, a substituted or unsubstituted aryl group or the like.]

1,3,5-SUBSTITUTED PHENYL DERIVATIVE COMPOUNDS USEFUL AS BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE

The present invention is directed to 1,3,5-phenyl substituted derivative compounds which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.

PHENYLCARBOXAMIDE BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE

The present invention is directed to compounds which are inhibitors of the beta-secretase enzyme and that are useful in the treatment or prevention of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is a