6953-39-5

Basic information

• Product Name: (5-nitro-1H-indol-3-yl)(oxo)acetic acid
• CAS NO: 6953-39-5
• Molecular Formula: C₁₀H₆N₂O₅
• Molecular Weight: 234.165
• Mol File: 6953-39-5.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 507.3°C at 760 mmHg
• Flash Point: 260.6°C
• Density: 1.674g/cm³
• Vapor Pressure: 4.1E-11mmHg at 25°C
• Refractive Index: 1.744
• CAS DataBase Reference: (5-nitro-1H-indol-3-yl)(oxo)acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (5-nitro-1H-indol-3-yl)(oxo)acetic acid(6953-39-5)
• EPA Substance Registry System: (5-nitro-1H-indol-3-yl)(oxo)acetic acid(6953-39-5)

Safety Data

• Hazardous Substances Data: 6953-39-5(Hazardous Substances Data)

Usage

Description

(5-nitro-1H-indol-3-yl)(oxo)acetic acid is a chemical compound with the molecular formula C10H7N2O6. It is a derivative of indole with a nitro group attached to the 5-position of the indole ring. (5-nitro-1H-indol-3-yl)(oxo)acetic acid also contains an oxoacetic acid moiety. It is used in various research applications, particularly in the synthesis of pharmaceuticals and organic compounds.
Used in Pharmaceutical Industry:
(5-nitro-1H-indol-3-yl)(oxo)acetic acid is used as a building block for the synthesis of pharmaceuticals and organic compounds. Its unique structure and functional groups make it a valuable component in the development of new drugs and therapeutic agents.
Used in Research Applications:
(5-nitro-1H-indol-3-yl)(oxo)acetic acid is used as a reagent in organic synthesis and in the development of new chemical entities with therapeutic potential. Its pharmacological activity has been studied for its anti-cancer and anti-inflammatory properties, making it a promising candidate for further research and development.
Used in Organic Synthesis:
(5-nitro-1H-indol-3-yl)(oxo)acetic acid is used as a reagent in organic synthesis to create a variety of chemical compounds. Its versatile structure and functional groups allow for the formation of new bonds and the synthesis of complex molecules.

Upstream product

• 79-37-8 oxalyl dichloride 
• 6146-52-7 5-nitroindole 
• 4771-10-2 1-(5-nitro-1H-indol-3-yl)ethan-1-one 
• 6953-35-1 2-(5-nitro-1H-indol-3-yl)-2-oxoacetyl chloride 

Downstream Products

• 6958-37-8 5-nitro-1H-indole-3-carboxylic acid 
• 1383933-29-6 N-benzyl-2-(1-methyl-5-nitro-1H-indol-3-yl)acetamide 
• 1383933-27-4 C₁₇H₁₅N₃O₃ 
• 79473-05-5 2-(5-nitro-1 H-indol-3-yl)acetic acid 
• 933447-89-3 methyl 1-[2-deoxy-3,5-bis(4-methylbenzoyl)-β-D-ribofuranosyl]-5-nitroindole-3-carboxylate 
• 686747-51-3 methyl 5-nitro-1H-indole-3-carboxylate 
• 933447-91-7 methyl 1-[2-deoxy-5-O-(4,4'-dimethoxytrityl)-β-D-ribofuranosyl]-5-nitroindole-3-carboxylate 

Relevant articles and documents

An efficient synthesis and biological evaluation of novel analogues of natural product Cephalandole A: A new class of antimicrobial and antiplatelet agents

Cephalandole A 2, a small indole alkaloid isolated from the Taiwanese orchid Cephalanceropsis gracilis (Orchidaceae), exhibits anticancer activity. Surprisingly, this natural product has not been evaluated for any other biological activity so far. To discover other novel potential of Cephalandole A 2, an efficient and economic synthetic protocol for novel Cephalandole A analogues 21a-o has been developed, in only 3 steps from using indole, and applied for their biological activity. Biological testing showed that Cephalandole A 2 and its novel analogues 21a-o exhibited potential antimicrobial and antiplatelet activity in preliminary assay. To the best of our knowledge, this is the first report of Cephalandole A 2 and its novel synthetic analogues 21a-o as a new class of antimicrobial and antiplatelet agents. In this study, 2 and other analogues i.e., 21b, 21d, 21i and 21o showed promising antimicrobial activity against the phytopathogenic bacteria and fungi. Cephalandole A 2, 21c, 21f and 21i, also showed potent antiplatelet activity.

Effect of a hydrogen bonding carboxamide group on universal bases

A number of aromatic universal base analogues have been described in the literature, but most are non-hydrogen bonding. We have examined the effect of introducing hydrogen bonding carboxamide groups onto the pyrrole ring of 5-nitroindole. The modified ana