6953-78-2

Usage

InChI:InChI=1/C5H4N2O3S/c8-3-1-2(4(9)10)6-5(11)7-3/h1H,(H,9,10)(H2,6,7,8,11)

Upstream product

• 16953-46-1 6-oxo-2-thioxo-1,2,3,6-tetrahydro-pyrimidine-4-carbaldehyde 
• 17356-08-0 thiourea 
• 108-56-5 diethyl oxaloacetate 
• 6633-65-4 6-oxo-2-thioxo-1,2,3,6-tetrahydro-pyrimidine-4-carboxylic acid ethyl ester 

Downstream Products

• 65-86-1 orotic acid 
• 127066-87-9 2-(3-{4-[(E)-2-(4-Chloro-phenyl)-vinyl]-phenoxy}-propylsulfanyl)-6-oxo-1,6-dihydro-pyrimidine-4-carboxylic acid 
• 127066-89-1 2-(3-{4-[(E)-2-(4-Bromo-phenyl)-vinyl]-phenoxy}-propylsulfanyl)-6-oxo-1,6-dihydro-pyrimidine-4-carboxylic acid 
• 127066-88-0 2-(5-{4-[(E)-2-(4-Chloro-phenyl)-vinyl]-phenoxy}-pentylsulfanyl)-6-oxo-1,6-dihydro-pyrimidine-4-carboxylic acid 
• 127066-90-4 2-(5-{4-[(E)-2-(4-Bromo-phenyl)-vinyl]-phenoxy}-pentylsulfanyl)-6-oxo-1,6-dihydro-pyrimidine-4-carboxylic acid 
• 6633-65-4 6-oxo-2-thioxo-1,2,3,6-tetrahydro-pyrimidine-4-carboxylic acid ethyl ester 
• 6339-80-6 Methyl ester of thioorotic acid 

Relevant academic research and scientific papers

A reexamination of the substrate utilization of 2-thioorotidine-5′ -monophosphate by yeast orotidine-5′ -monophosphate decarboxylase

A potential alternate substrate for orotidine-5′-monophosphate decarboxylase, 2- thio-orotidine-5′-monophosphate, was synthesized enzymatically and purified by a modification of a previous account (K. Shostak, and M. E. Jones 1992, Biochemistry 31, 12155-12161). Characterization of the product was confirmed by mass spectrometry, 31P NMR, and utilization by orotate phosphoribosyltransferase in the direction of pyrophosphorolysis. The previous work probably did not result in the purification of the desired compound, as evidenced by our observation of 2-thioOMP's sensitivity to high temperature, as used previously. Using a very sensitive HPLC assay for the potential decarboxylated product 2-thioUMP, no measurable activity of ODCase toward the alternate substrate was observed, representing a decarboxylation rate decreased by 10-7 from the kcat for ODCase toward OMP. Additionally, 2-thioOMP effects no inhibition of ODCase decarboxylation of OMP at a concentration of 50 μM, indicating a poor ability to bind to the ODCase active site. The results bear implications for proposed mechanisms for catalysis by ODCase.

Composition of matter having bioactive properties

Particles of coordinated complex comprising a basic, hydrous polymer and a capacitance adding compound, as well as methods for their production, are described. These complexes exhibit a high degree of bioactivity making them suitable for a broad range of applications through their incorporation into conventional vehicles benefiting from antimicrobial and similar properties.

Thiouracil derivatives and metal surface-treating agent comprising thereof

A thiouracil derivative represented by the following general formula (1) or (2) STR1 (wherein, R1 and R2 each are a hydrogen atom or an alkyl group, and at least one of R1 and R2 is a hydrogen atom, and R3 is a hydrogen atom, an alkyl group or a phenyl group, and R4 is a bivalent saturated hydrocarbon group having 2 to 12 carbon atoms, Z is --COO--, CH2 O-- or --C6 H4 --CH2 O--, and R5 is a hydrogen atom or a methyl group), and a metal surface-treating agent for bonding a metal, particularly a noble metal to a resin or the like in high adhesive strength and in high water resistance and high durability which contains the above thiouracil derivative and an organic solvent such as acetone or ethanol.

Novel thiouracil derivatives and metal surface-treating agent comprising thereof

A thiouracil derivative of formula (1) or (2) wherein, R1and R2are each a hydrogen atom or an alkyl group, and at least one of R1and R2is a hydrogen atom, R3is a hydrogen atom, an alkyl group or a phenyl group, R4is a bivalent saturated C2-12hydrocarbon group, Z is -COO-, CH2O- or -C6H4-CH2O-, and R5is a hydrogen atom or a methy group, and a metal surface-treating agent for bonding a metal comprising the derivative and an organic solvent.