69557-34-2Relevant academic research and scientific papers
Radical migration-addition of N-tert-butanesulfinyl imines with organozinc reagents
Huang, Wei,Ye, Jian-Liang,Zheng, Wei,Dong, Han-Qing,Wei, Bang-Guo
, p. 11229 - 11237 (2013/12/04)
A novel migration-addition sequence was discovered for the reaction of enantioenriched N-tert-butanesulfinyl iminoacetate 1a with functionalized benzylzinc bromide reagents, producing tert-leucine derivatives in excellent diastereoselectivity (dr 98:2). The absolute configurations of two new chiral centers were unambiguously assigned by chemical transformations and X-ray crystallography. In addition, the regio- and diastereoselectivities of this novel reaction were both explained through the key N-sulfinamine intermediate M6 generated by the tert-butyl radical attack on the imine. Computational analysis of this reaction process, which was performed at the B3LYP/6-311++G(3df,2p)//B3LYP/6-31G-LANL2DZ level, also supported our proposed two-stage mechanism.
Substituted Carbonyloxymethylphosphoramidate Compounds and Pharmaceutical Compositions for the Treatment of Viral Infections
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Paragraph 0501; 0502, (2013/03/27)
Provided herein are compounds, compositions and methods for the treatment of liver disorders, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or i
Diastereoselective addition of organozinc reagents to chiral α-imino esters
Chiev, Kan Pa,Roland, Sylvain,Mangeney, Pierre
, p. 2205 - 2209 (2007/10/03)
The addition of organozinc reagents to chiral α-imino esters pre-complexed with zinc bromide, occurred with complete regioselectivity at the imino carbon. The influence of the solvent, temperature and different chiral auxiliaries was studied. The best diastereoselectivities were obtained in Et2O or CH2Cl2 at 0°C, using phenylglycinol methyl ether as the chiral inductor.
