6957-95-5

Basic information

• Product Name: 2H-Isoindole-2-aceticacid, 1,3-dihydro-a-[(4-nitrophenyl)methyl]-1,3-dioxo-, ethyl ester
• Synonyms: 2-Isoindolineaceticacid, a-(p-nitrobenzyl)-1,3-dioxo-,ethyl ester (6CI,7CI); NSC 19761
• CAS NO: 6957-95-5
• Molecular Formula: C₁₉H₁₆N₂O₆
• Molecular Weight: 368.3401
• Mol File: 6957-95-5.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 548°Cat760mmHg
• Flash Point: 285.2°C
• Density: 1.396g/cm³
• CAS DataBase Reference: 2H-Isoindole-2-aceticacid, 1,3-dihydro-a-[(4-nitrophenyl)methyl]-1,3-dioxo-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-Isoindole-2-aceticacid, 1,3-dihydro-a-[(4-nitrophenyl)methyl]-1,3-dioxo-, ethyl ester(6957-95-5)
• EPA Substance Registry System: 2H-Isoindole-2-aceticacid, 1,3-dihydro-a-[(4-nitrophenyl)methyl]-1,3-dioxo-, ethyl ester(6957-95-5)

Safety Data

• Hazardous Substances Data: 6957-95-5(Hazardous Substances Data)

Upstream product

• 64-17-5 ethanol 
• 131175-70-7 (R)-N-phthaloyl-p-nitrophenylalanine 
• 100-14-1 4-nitrobenzyl chloride 
• 85-44-9 phthalic anhydride 
• 780004-06-0 C₁₁H₁₄N₂O₄ 
• 147065-06-3 (R)-4-nitrophenyl-alanine-hydrochloride 
• 88546-12-7 methyl (R)-2-acetamido-3-(4-nitrophenyl)propanoate 
• 555-16-8 4-nitrobenzaldehdye 
• 60666-01-5 (RS)-N-phthaloyl-p-nitrophenylalanine 
• 855633-22-6 (4-nitro-benzyl)-phthalimido-malonic acid diethyl ester 
• 101445-16-3 N-(2-carboxy-benzoyl)-4-nitro-phenylalanine 
• 93963-19-0 N-(2-carboxy-benzoyl)-4-nitro-D-phenylalanine ethyl ester 

Downstream Products

• 116604-68-3 4-dimethylamino-N,N-phthaloyl-D-phenylalanin-ethyl ester 
• 1195524-16-3 4-amino-N,N-phthaloyl-D-phenylalanin-ethyl ester 
• 93942-39-3 C₂₃H₂₄Cl₂N₂O₄ 

Relevant articles and documents

Melphalan intermediate and preparation method thereof

The invention discloses a Melphalan intermediate and a preparation method thereof. The Melphalan intermediate is prepared by acidifying a compound p-nitrobenzaldehyde under the action of methanol, a hydrochloric acid solvent, etc. The preparation method has a route with mild reaction conditions, is higher than an existing preparation method in yield, is economical and effective, and is suitable for large-scale industrial production. The synthesis route is as shown in the description.