6958-33-4 Usage
Main Properties
1. Chemical Name: 2-amino-6-(4-nitrophenyl)-4-(2,4,5-trimethoxyphenyl)pyridine-3-carbonitrile
2. Chemical Structure: Complex structure comprising a pyridine ring with various substituents.
3. Functional Groups:
Amino Group (NH2): Attached to position 2 of the pyridine ring.
Nitro Group (NO2): Attached to position 6 of the pyridine ring.
Methoxy Groups (OCH3): Three groups attached to the phenyl ring at positions 2, 4, and 5.
Carbonitrile Group (CN): Attached to position 3 of the pyridine ring, adding to its chemical versatility.
4. Biological Activities/Pharmaceutical Potential: Potential biological activities or pharmaceutical applications due to its structural features.
5. Research Implications: Further research may be warranted to explore its properties and potential uses in various fields.
Amino Group
NH2 group attached at position 2 of the pyridine ring.
Nitro Group
NO2 group attached at position 6 of the pyridine ring.
Methoxy Groups
Three OCH3 groups attached to the phenyl ring at positions 2, 4, and 5.
Carbonitrile Group
CN group attached at position 3 of the pyridine ring.
Chemical Versatility
Presence of the carbonitrile group enhances its potential applications in chemical reactions and synthesis.
Biological/Pharmaceutical Potential
Structural features suggest potential activities or applications in biological and pharmaceutical contexts.
Need for Further Research
Additional investigation is needed to fully understand its properties and potential uses in various fields.
2-amino-6-(4-nitrophenyl)-4-(2,4,5-trimethoxyphenyl)pyridine-3-carbonitrile's structural complexity and combination of functional groups make it intriguing for further study in both chemical and biological contexts.
Check Digit Verification of cas no
The CAS Registry Mumber 6958-33-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,9,5 and 8 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 6958-33:
(6*6)+(5*9)+(4*5)+(3*8)+(2*3)+(1*3)=134
134 % 10 = 4
So 6958-33-4 is a valid CAS Registry Number.
6958-33-4Relevant academic research and scientific papers
Discovery of IDO1 and DNA dual targeting antitumor agents
Fang, Kun,Wu, Shanchao,Dong, Guoqiang,Wu, Ying,Chen, Shuqiang,Liu, Jianhe,Wang, Wei,Sheng, Chunquan
supporting information, p. 9992 - 9995 (2017/12/26)
The development of small molecules for cancer immunotherapy is highly challenging and indoleamine 2,3-dioxygenase 1 (IDO1) represents a promising target. Inspired by the synergistic effects between IDO1 inhibitors and traditional antitumor chemotherapeutics, the first orally active dual IDO1 and DNA targeting agents were designed by the pharmacophore fusion strategy. The bifunctional hybrids exhibited enhanced IDO1 enzyme inhibitory activity and in vitro cytotoxicity as compared to IDO1 inhibitor 1-methyl-tryptophan and DNA alkylating agent melphalan. In a murine LLC tumor model, the dual targeting agents demonstrated excellent antitumor efficacy, highlighting the advantages of this novel design strategy to improve the efficacy of small molecule cancer immunotherapy.
Synthesis and NMR characteristics of N-acetyl-4-nitro, N-acetyl-5-nitro, N-acetyl-6-nitro and N-acetyl-7-nitrotryptophan methyl esters
King, Russell R.,Calhoun, Larry A.
experimental part, p. 273 - 276 (2009/12/28)
N-acetyl-4-nitrotryptophan methyl ester (2), N-acetyl-5-nitrotryptophan methyl ester (3), N-acetyl-6-nitrotryptophan methyl ester (4) and N-acetyl-7-nitrotryptophan methyl ester (5) were synthesized through a modified malonic ester reaction of the appropriate nitrogramine analogs followed by methylation with BF3-methanol. Assignments of the 1H and 13C NMR chemical shifts were made using a combination of 1H-1H COSY, 1H-13C HETCOR and 1H-13C selective INEPT experiments. Copyright
