6958-43-6

Usage

General Description

2-amino-4-(2-fluorophenyl)-6-(2-nitrophenyl)pyridine-3-carbonitrile is a chemical compound with the molecular formula C19H11FN4O2. It is a pyridine derivative that contains an amino group, a fluorophenyl group, a nitrophenyl group, and a carbonitrile group. 2-amino-4-(2-fluorophenyl)-6-(2-nitrophenyl)pyridine-3-carbonitrile is used in the field of medicinal chemistry and pharmaceutical research, and it has potential applications as a building block for the synthesis of various biologically active molecules. Its unique structure and properties make it a valuable tool for the development of new drugs and therapeutic agents. Additionally, the presence of the fluorophenyl and nitrophenyl groups in the compound may also give it interesting pharmacological activities, which could be explored further in future studies. Overall, 2-amino-4-(2-fluorophenyl)-6-(2-nitrophenyl)pyridine-3-carbonitrile is a versatile and promising chemical compound with potential for various applications in the field of drug discovery and development.

Upstream product

• 100-52-7 benzaldehyde 
• 3619-22-5 p-toluic hydrazide 

Downstream Products

• 928151-54-6 trans-[Ru(III)(C₆H₄CHNNC(4-Me-C₆H₄)O)(PPh₃)2Cl] 
• 1874-47-1 2-(4-methylphenyl)-5-phenyl-1,3,4-oxadiazole 
• 142969-01-5 2-phenyl-3-acetyl-5-(4-methylphenyl)-2,3-dihydro-1,3,4-oxadiazole 

Relevant academic research and scientific papers

Harnessing Autoxidation of Aldehydes: In Situ Iodoarene Catalyzed Synthesis of Substituted 1,3,4-Oxadiazole, in the Presence of Molecular Oxygen

Isobutyraldehyde underwent auto-oxidation in the presence of molecular oxygen to generate an acyloxy radical under a "metal-free" environment. They were subsequently exploited in situ to afford hypervalent iodines with p-anisolyl iodide which generated substituted 1,3,4-oxadiazoles in moderate to excellent yields from N′-arylidene acetohydrazides. The reaction strategy tolerated diverse substitution on the hydrazide substrates. Control experiments and literature precedence supported the formation of an in situ iodosylarene complex that facilitates the formation of products.

3-Acetyl-2,5-diaryl-2,3-dihydro-1,3,4-oxadiazoles: A new scaffold for the selective inhibition of monoamine oxidase B

3-Acetyl-2,5-diaryl-2,3-dihydro-1,3,4-oxadiazoles were designed, synthesized, and tested as inhibitors against human monoamine oxidase (MAO) A and B isoforms. Several compounds, obtained as racemates, were identified as selective MAO-B inhibitors. The enantiomers of some derivatives were separated by enantioselective HPLC and tested. The R-enantiomers always showed the highest activity. Docking study and molecular dynamic simulations demonstrated the putative binding mode. We conclude that these 1,3,4-oxadiazoles derivatives are promising reversible and selective MAO-B inhibitors.

Benzylidene/2-chlorobenzylidene hydrazides: Synthesis, antimicrobial activity, QSAR studies and antiviral evaluation

A series of benzylidene hydrazides (1-20) was synthesized and tested, in vitro, for antibacterial, antifungal and antiviral activities. The microbial screening results indicated that compounds having chloro and nitro substituents were the most active ones. The antiviral evaluation depicted that compounds 9 and 19 were active against Vesicular stomatitis virus (VSV) in HeLa cell cultures. QSAR investigations indicated that the multi-target QSAR model was effective in describing the antimicrobial (antibacterial and antifungal) activity over the one-target QSAR models. Further the mt-QSAR model indicated that the topological parameters, second order molecular connectivity index (2χ) and third order Kier's alpha shape index (κα3) are effective in describing the antimicrobial activity of synthesized hydrazides.