69584-91-4

Usage

Uses

1,2-Dihydro-1''-methylspiro[3h-indole-3,4''-piperidine]

Upstream product

• 55-86-7 mechlorethamine hydrochloride 
• 85422-39-5 (4-(2-fluorophenyl)-1-methylpiperidin-4-yl) methanamine 
• 184289-84-7 benzyl 1-(methylsulfonyl)spiro[indoline-3,4’-piperidine]-1‘-carboxylate 
• 326-62-5 2-fluorophenyl acetonitrile 
• 69584-88-9 4-(2-fluorophenyl)-1-methylpiperidine-4-carbonitrile 

Downstream Products

• 69585-02-0 1-phenyl-1'-methylspiro[indoline-3,4'-piperidine] 
• 69585-10-0 1-(2-chlorophenyl)-1'-methylspiro[indoline-3,4'-piperidine] 
• 69585-04-2 C₁₉H₂₁FN₂ 
• 69584-96-9 1'-methyl-1-[(4-trifluoromethyl)-phenyl]spiro[indoline-3,4'-piperidine] 
• 69584-99-2 C₂₀H₂₁F₃N₂ 
• 167483-90-1 1-benzyloxycarbonyl-1'-methylspiro(indoline-3,4'-piperidine) 
• 81049-90-3 1-(2-nitrophenyl)spiro[indoline-3,4'-piperidine] 
• 75391-68-3 1-(2-aminophenyl)-1'-methylspiro[indoline-3,4'-piperidine] 
• 81049-95-8 C₁₈H₁₉ClN₂ 
• 81049-92-5 C₁₈H₂₁N₃ 
• 69585-07-5 1-(4-fluorophenyl)spiro[indoline-3,4'-piperidine] 
• 81049-99-2 1'-carbamoyl-1-(2-nitrophenyl)spiro 
• 81049-89-0 C₁₉H₁₈N₄O₂ 
• 75391-72-9 C₁₉H₁₈FN₃ 

Relevant academic research and scientific papers

1'-methylspiro[indoline-3,4'-piperidine] derivatives: Design, synthesis, molecular docking and anti-tumor activity studies

Background: Spirocyclic indoline compounds widely exist in numerous natural products and synthetic molecules with significant biological activities. In recent years, these kinds of compounds have attracted extensive attention as potent anti-tumor agents i

CYCLOALKANOPYRIDINE DERIVATIVE

Provided are cycloalkanopyridine derivatives of formula [I]: [wherein the symbols are the same as those stated in the description]. The compounds act as a nociceptin receptor antagonist, and are useful as medicines for diseases associated with a nociceptin receptor, for example, as a reliever against tolerance to a narcotic analgesic; a reliever against dependence on or addiction to a narcotic analgesic; an analgesic enhancer; an antiobesitic or appetite suppressor; a treating or prophylactic agent for cognitive impairment and dementia/amnesia; an agent for treating developmental cognitive abnormality; a remedy for schizophrenia; an agent for treating neurodegenerative diseases; an anti-depressant or treating agent for affective disorder; a treating or prophylactic agent for diabetes insipidus; a treating or prophylactic agent for polyuria; or a remedy for hypotension.

Novel tetracyclic spiropiperidines. III. 1-Arylspiro[indoline-3,4'-piperidine]s as potential antidepressants

A series of 1-arylspiro[indoline-3,4'-piperidine]s was synthesized and evaluated for potential antidepressant activity by tetrabenazine (TBZ) ptosis prevention and potentiation of 5-hydroxytryptophan (5-HTP) induced head twitching in pargyline-pretreated