69595-64-8Relevant academic research and scientific papers
One-Pot Synthesis of N-Alkyl Benzotriazoles via a Br?nsted Acid-Catalyzed Three-Component Reaction
Wang, Xiangdong,Jia, Chunqi,Feng, Yadong,Wang, Lianhui,Cui, Xiuling
supporting information, p. 374 - 378 (2017/11/16)
A novel three-component condensation reaction of benzotriazoles, aldehydes and tertiary anilines efficiently catalyzed by readily available organic acid p-toluenesulfonic acid (PTSA) has been developed. A series of N-alkyl benzotriazoles were synthesized in up to 97% yield for 21 examples starting from anilines, benzotriazoles and formaldehyde. This strategy features a simple system, atom economy, environmental friendliness, high efficiency, excellent regioselectivity, good functional group tolerance, easily available starting materials, and cheap catalyst. The mechanistic studies indicated that aza quinone methide was probably involved as an intermediate in this transformation. (Figure presented.).
