696-02-6

Basic information

• Product Name: 1-Chloro-3,4-difluorobenzene
• Synonyms: Benzene,4-chloro-1,2-difluoro-;1-Chloro-3,4-difluorobenzene, 97% [4-Chloro-1,2-difluorobenzene];1-Chloro-3,4-difluorobenzene~3,4-Difluorochlorobenzene;4-BROMO-2-BENZONITRILE-4-CHLORO-1,2-DIFLUOROBENZENE;1-Chloro-3,4-difluorobenzene 98%;1-Chloro-3,4-difluorobenzene98%;1-Chloro-3,4-difluorobenzene,99%;4-Bromo-2-Benzonitri
• CAS NO: 696-02-6
• Molecular Formula: C₆H₃ClF₂
• Molecular Weight: 148.54
• EINECS: -0
• Product Categories: Aromatic Hydrocarbons (substituted) & Derivatives;Heterocyclic Compounds;Chlorine Compounds;Fluorine Compounds;Aryl;C6;Halogenated Hydrocarbons;Fluorine series;Halogenated Heterocycles ,Thiophenes
• Mol File: 696-02-6.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 126 °C(lit.)
• Flash Point: 96 °F
• Appearance: Clear colourless to light yellow liquid
• Density: 1.33 g/mL at 25 °C(lit.)
• Refractive Index: n20/D 1.475(lit.)
• Storage Temp.: Sealed in dry,Room Temperature
• BRN: 2081081
• CAS DataBase Reference: 1-Chloro-3,4-difluorobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Chloro-3,4-difluorobenzene(696-02-6)
• EPA Substance Registry System: 1-Chloro-3,4-difluorobenzene(696-02-6)

Safety Data

• Hazard Codes: Xn,F,Xi,N
• Statements: 10-22-36/37/38
• Safety Statements: 16-26-36-37/39
• RIDADR: UN 1993 3/PG 3
• WGK Germany: 3
• HazardClass: 3
• PackingGroup: III
• Hazardous Substances Data: 696-02-6(Hazardous Substances Data)

Usage

Chemical Properties

Clear colourless to light yellow liquid

Uses

4-Chloro-1,2-difluorobenzene may be used in the preparation of 1-chloro-4,5-difluoro-2-nitrobenzene.

General Description

4-Chloro-1,2-difluorobenzene is a halogenated benzene derivative. Its proton shielding has been computed using ab initio methods.

InChI:InChI=1/C6H3ClF2/c7-4-1-2-5(8)6(9)3-4/h1-3H

Upstream product

• 356-77-4 1,1,2,2-tetrafluoro-3-vinylcyclobutane 
• 2646-83-5 3,3,4,4-tetrafluorocyclohexene 
• 108-90-7 chlorobenzene 
• 360-47-4 3-(1-chloro-vinyl)-1,1,2,2-tetrafluoro-cyclobutane 
• 356-96-7 1-chloro-2,2,3,3-tetrafluoro-1-vinyl-cyclobutane 
• 3863-11-4 3,4-difluoroaniline 
• 89-61-2 2,5-dichloronitrobenzene 
• 2106-05-0 5-chloro-2-fluoroaniline 
• 345-18-6 2-fluoro-5-chloronitrobenzene 
• 367-11-3 ortho-difluorobenzene 
• 106-46-7 para-dichlorobenzene 

Downstream Products

• 133117-00-7 2-chloro-4,5-difluoro-α-chloroacetophenone 
• 59447-06-2 1-bromo-2-chloro-4,5-difluorobenzene 
• 38964-22-6 2,8-dichlorodibenzodioxin 
• 1552281-02-3 4-(5-chloro-4-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamido)-2-fluorophenoxy)picolinamide 
• 847872-10-0 4-amino-5-chloro-2-fluoro-phenol 
• 1437034-25-7 (R)-2-(4-(5-chloro-2-fluorophenoxy)phenyl)-6-(1,2-dihydroxyethyl)pyrimidine-4-carboxamide 
• 1437034-77-9 C₁₉H₁₃ClFN₃O₂ 
• 1437034-76-8 C₁₉H₁₂ClFN₂O₃ 
• 1437034-72-4 2-(4-(5-chloro-2-fluorophenoxy)phenyl)-4,4,5,5-tetramethyl-1,3,3-dioxaborolane 
• 1374400-73-3 methyl 3-(3,4-difluorophenyl)indolizine-2-carboxylate 
• 1299490-15-5 7-(2'-chloro-4',5'-difluoro-biphenyl-4-yloxymethyl)-3-trityloxy-benzo[d]isoxazole 
• 1299490-13-3 7-(2'-chloro-4',5'-difluoro-biphenyl-4-yloxymethyl)-benzo[d]isoxazol-3-ol 
• 367-11-3 ortho-difluorobenzene 
• 1214273-28-5 C₁₂H₁₅BF₂O₂ 

Relevant articles and documents

Three-step regioselective synthesis of 2,3-difluorohalobenzenes using tetrafluoroethylene and buta-1,3-diene as starting building blocks

The gas-phase copyrolysis of tetrafluoroethylene and buta-1,3-diene in a flow tube reactor at 490–510 °C gives 3,3,4,4-tetrafluorocyclohex-1-ene, which is selectively converted to 1-bromo- or 1-chloro-2,3-difluorobenzene via intermediate steps of halogenation and dehydrohalogenation.

Method for producing tetrakis ( fluoroaryl) borate-magnesium compound

Fluoroaryl magnesium halide is reacted with a boron compound so that a molar ratio of the fluoroaryl magnesium halide to the boron compound is not less than 3.0 and not more than 3.7, so as to produce a tetrakis (fluoroaryl) borate·magnesium compound. With this method, there occurs no hydrogen fluoride which corrodes a producing apparatus and requires troublesome waste water treatment.

Process for producing chlorofluorobenzenes

A process for producing chlorofluorobenzenes, which comprises reacting fluorine-containing nitrobenzenes of the following formula (1) with chlorine gas to obtain chlorofluorobenzenes of the following formula (2): STR1 wherein n and m are integers satisfying 1≤n≤3, 0≤m≤2 and 1≤n+m≤3.