696-02-6

Usage

Uses

Used in Chemical Synthesis:
1-Chloro-3,4-difluorobenzene is used as a key intermediate in the synthesis of various organic compounds and pharmaceuticals. Its presence of chlorine and fluorine atoms allows for further functionalization and the formation of a wide range of derivatives.
Used in Pharmaceutical Industry:
1-Chloro-3,4-difluorobenzene is used as a building block for the development of new drugs and pharmaceutical agents. Its unique structure and reactivity make it a valuable component in the design and synthesis of novel therapeutic agents.
Used in Agrochemical Industry:
1-Chloro-3,4-difluorobenzene is used as a precursor in the production of agrochemicals, such as insecticides, herbicides, and fungicides. Its chemical properties enable the development of effective and targeted pest control solutions.
Used in Dye and Pigment Industry:
1-Chloro-3,4-difluorobenzene is used as a starting material for the synthesis of dyes and pigments. Its ability to form various derivatives allows for the creation of a diverse range of colorants for use in various applications, such as textiles, plastics, and printing inks.
Used in Preparation of 1-Chloro-4,5-difluoro-2-nitrobenzene:
1-Chloro-3,4-difluorobenzene is used as a reactant in the preparation of 1-chloro-4,5-difluoro-2-nitrobenzene, which is an important compound for further chemical transformations and applications in various industries.

InChI:InChI=1/C6H3ClF2/c7-4-1-2-5(8)6(9)3-4/h1-3H

Upstream product

• 106-46-7 para-dichlorobenzene 
• 108-90-7 chlorobenzene 
• 367-11-3 ortho-difluorobenzene 
• 3863-11-4 3,4-difluoroaniline 
• 360-47-4 3-(1-chloro-vinyl)-1,1,2,2-tetrafluoro-cyclobutane 
• 356-96-7 1-chloro-2,2,3,3-tetrafluoro-1-vinyl-cyclobutane 
• 356-77-4 1,1,2,2-tetrafluoro-3-vinylcyclobutane 
• 2646-83-5 3,3,4,4-tetrafluorocyclohexene 
• 89-61-2 2,5-dichloronitrobenzene 
• 2106-05-0 5-chloro-2-fluoroaniline 
• 345-18-6 2-fluoro-5-chloronitrobenzene 

Downstream Products

• 85312-59-0 3,4-difluoro-4'-(trans-4-propylcyclohexyl)-1,1'-biphenyl 
• 121872-94-4 2'-chloro-4',5'-difluoroacetophenone 
• 110877-64-0 2-chloro-4,5-difluorobenzoic acid 
• 367-11-3 ortho-difluorobenzene 
• 1214273-28-5 C₁₂H₁₅BF₂O₂ 
• 1552281-02-3 4-(5-chloro-4-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamido)-2-fluorophenoxy)picolinamide 
• 847872-10-0 4-amino-5-chloro-2-fluoro-phenol 
• 1437034-25-7 (R)-2-(4-(5-chloro-2-fluorophenoxy)phenyl)-6-(1,2-dihydroxyethyl)pyrimidine-4-carboxamide 
• 1437034-77-9 C₁₉H₁₃ClFN₃O₂ 
• 1437034-76-8 C₁₉H₁₂ClFN₂O₃ 
• 1437034-72-4 2-(4-(5-chloro-2-fluorophenoxy)phenyl)-4,4,5,5-tetramethyl-1,3,3-dioxaborolane 
• 1374400-73-3 methyl 3-(3,4-difluorophenyl)indolizine-2-carboxylate 
• 59447-06-2 1-bromo-2-chloro-4,5-difluorobenzene 
• 1299490-15-5 7-(2'-chloro-4',5'-difluoro-biphenyl-4-yloxymethyl)-3-trityloxy-benzo[d]isoxazole 

Relevant academic research and scientific papers

Three-step regioselective synthesis of 2,3-difluorohalobenzenes using tetrafluoroethylene and buta-1,3-diene as starting building blocks

The gas-phase copyrolysis of tetrafluoroethylene and buta-1,3-diene in a flow tube reactor at 490–510 °C gives 3,3,4,4-tetrafluorocyclohex-1-ene, which is selectively converted to 1-bromo- or 1-chloro-2,3-difluorobenzene via intermediate steps of halogenation and dehydrohalogenation.

Reactions of aromatic compounds with xenon difluoride

Reactions of substituted benzenes C6H5R (R = Me, F, Cl, Br, CF3, NO2) with xenon difluoride in the presence of boron trifluoride–diethyl ether complex in weakly acidic (1,1,1,3,3-pentafluorobutane) and weakly basic media (acetonitrile) have been studied. These reactions lead to the formation of fluorobenzene derivatives FC6H4R (isomer mixture) together with isomeric difluorobenzenes and fluorinated and non-fluorinated biphenyls. The results have been compared with previously reported data obtained in other solvents using other catalysts.

Method for producing tetrakis ( fluoroaryl) borate-magnesium compound

Fluoroaryl magnesium halide is reacted with a boron compound so that a molar ratio of the fluoroaryl magnesium halide to the boron compound is not less than 3.0 and not more than 3.7, so as to produce a tetrakis (fluoroaryl) borate·magnesium compound. With this method, there occurs no hydrogen fluoride which corrodes a producing apparatus and requires troublesome waste water treatment.

Process for producing chlorofluorobenzenes

A process for producing chlorofluorobenzenes, which comprises reacting fluorine-containing nitrobenzenes of the following formula (1) with chlorine gas to obtain chlorofluorobenzenes of the following formula (2): STR1 wherein n and m are integers satisfying 1≤n≤3, 0≤m≤2 and 1≤n+m≤3.

Process for preparing chloro-difluorobenzene

1-Chloro-3,4-difluoro-benzene, an intermediate in the production of certain quinolone drugs, is produced by converting a chlorofluoro-aniline into the corresponding diazonium fluoborate, and pyrolysing the latter to give the 1-chloro-3,4-difluorobenzene.

Preparation of substituted fluorobenzenes

Substituted fluorobenzenes are produced by pyrolyzing vinylfluorocyclobutanes at a temperature of 250°-450° C. in the presence of activated carbon or certain metal oxides or mixtures of metal oxides.

New Method for Selective Monofluorination of Aromatics Using Silver Difluoride

Fluorobenzene is obtained in 61percent yield from reaction of a solution of benzene in n-hexane with solid argentic fluoride (AgF2).The AgF2 acts as both a strong oxidant and the fluoride source.Cobaltic fluoride provides only low (8percent) yields of fluorobenzene under similar conditions.The predominant reaction of benzene solutions with AgF2 appears to proceed by a process involving initial electrophilic oxidative cis addition of two fluorine atoms from the solid AgF2 lattice to the para aromatic positions, leading to cis-3,6-difluoro-1,4-cyclohexadiene (F2CHD).The reductive elimination leaves solid argentous fluoride (AgF) which is easily recoverable by filtration.Elimination of HF from the F2CHD yields fluorobenzene.Reactions of haloaromatics with AgF2 generally proceed in a similar manner.Thus, further reaction of AgF2 with benzene or monohalo- or p-dihalobenzenes leads in steps to 3,3,6,6-tetrafluoro-1,4-cyclohexadiene (F4CHD) in up to 82percent yield.The modest to high yields of mono- and specific polyfluorinated aromatics contrast sharply with reported nonselective perfluorination in vapor-phase reactions of aromatics over AgF2 or CoF3.Reactions of AgF2 or CoF3 with solutions of nitrobenzene, acetophenone, benzoic acid, and benzonitrile give mixtures of o-, m-, and p-monofluoro derivatives.