696-11-7

Usage

General Description

2,4(1H,3H)-Pyrimidinedione, dihydro-1-methyl- is a chemical compound with the molecular formula C5H6N2O2. It is also known by the alternative names 1-Methyl-2,4-dihydro-3,4-dioxopyrimidine and 1-Methyluracil. 2,4(1H,3H)-Pyrimidinedione, dihydro-1-methyl- is a white crystalline solid that is soluble in water and organic solvents. It is commonly used as an intermediate in the synthesis of pharmaceuticals, particularly in the production of antiviral and antimicrobial agents. Additionally, it has applications in the manufacturing of dyes and pigments. The compound has a wide range of industrial and pharmaceutical uses due to its versatile chemical properties and reactivity.

InChI:InChI=1/C5H8N2O2/c1-7-3-2-4(8)6-5(7)9/h2-3H2,1H3,(H,6,8,9)

Upstream product

• 615-77-0 1-methyluracil 
• 24549-12-0 methyl 3-(methylamino)propanoate 
• 1408064-50-5 methyl 3-(N-methylcyanamido)propanoate 
• 119740-95-3 methyl 3-(N-tert-butoxycarbonyl-N-methyl)-aminopropionate 
• 54434-24-1 N-methyl,N-(β-cyanoethyl)-cyanamide 
• 72054-55-8 3-(1-methylureido)-propanoic acid 
• 2213-08-3 ethyl 3-methylaminopropionate 

Downstream Products

• 156918-68-2 3-(10-Undecenyl)-1-methylhydrouracil 
• 6306-81-6 1-Methyl-5-brom-5.6-dihydro-uracil 

Relevant academic research and scientific papers

Transfer hydrogenation as a redox process in nucleotides

Using a combined theoretical and experimental strategy, the heats of hydrogenation of the nucleotide bases uracil, thymine, cytosine, adenine, and guanine have been determined. The most easily hydrogenated base is uracil, followed by thymine and cytosine. Comparison of these hydrogenation enthalpies with those of ketones and aldehydes derived from sugar models indicates the possibility of near-thermoneutral hydrogen transfer between uracil and the sugar phosphate backbone in oligonucleotides. (Figure Presented)

Dibutylphosphate (DBP) mediated synthesis of cyclic N,N′- disubstituted urea derivatives from amino esters: A comparative study

The N,N′-disubstituted urea derivatives such as amino acid hydantoins and dihydrouracil derivatives were prepared starting from natural and unnatural amino acid esters using dibutylphosphate (DBP). During the attempted synthesis of N-heterocycles with larger than six-membered rings containing the N,N′-disubstituted urea functionalities, three unexpected products namely squamolone, N-methyl pyrrolidine-2-one, and diketopiperazine were isolated.

PROCESS FOR STRAIGHTENING KERATIN FIBRES WITH A HEATING MEANS AND DENATURING AGENTS

The invention relates to a process for straightening keratin fibres, comprising: (i) a step in which a straightening composition containing at least two denaturing agents is applied to the keratin fibres, (ii) a step in which the temperature of the keratin fibres is raised, using a heating means, to a temperature of between 110 and 250° C.

DIHYDROURACIL COMPOUNDS AS ANTI-ICTOGENIC OR ANTI-EPILEPTOGENIC AGENTS

Methods and compounds useful for the inhibition of convulsive disorders, including epilepsy, are disclosed. The methods and compounds of the invention inhibit or prevent or treat ictogenesis, epileptogenesis, or epileptogenesis-associated conditions. Methods for preparing the compounds of the invention are also described. Particularly preferred compounds of the invention include Formula 1 as described herein.