696-11-7

Basic information

• Product Name: 2,4(1H,3H)-Pyrimidinedione, dihydro-1-methyl-
• Synonyms: 2,4(1H,3H)-Pyrimidinedione, dihydro-1-methyl-;5-broMo-1-Methyl-dihydro-pyriMidine-2,4-dione;Dihydro-1-Methyluracil;1-methyldihydro-2,4(1H,3H)-pyrimidinedione;1-methyl-1,3-diazinane-2,4-dione
• CAS NO: 696-11-7
• Molecular Formula: C₅H₈N₂O₂
• Molecular Weight: 128.13
• Mol File: 696-11-7.mol
• Article Data: 4

Chemical Properties

• Melting Point: 129-131 °C
• Appearance: /
• Density: 1.202g/cm³
• Refractive Index: 1.481
• PKA: 13.14±0.20(Predicted)
• CAS DataBase Reference: 2,4(1H,3H)-Pyrimidinedione, dihydro-1-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4(1H,3H)-Pyrimidinedione, dihydro-1-methyl-(696-11-7)
• EPA Substance Registry System: 2,4(1H,3H)-Pyrimidinedione, dihydro-1-methyl-(696-11-7)

Safety Data

• Hazardous Substances Data: 696-11-7(Hazardous Substances Data)

Usage

General Description

2,4(1H,3H)-Pyrimidinedione, dihydro-1-methyl- is a chemical compound with the molecular formula C5H6N2O2. It is also known by the alternative names 1-Methyl-2,4-dihydro-3,4-dioxopyrimidine and 1-Methyluracil. 2,4(1H,3H)-Pyrimidinedione, dihydro-1-methyl- is a white crystalline solid that is soluble in water and organic solvents. It is commonly used as an intermediate in the synthesis of pharmaceuticals, particularly in the production of antiviral and antimicrobial agents. Additionally, it has applications in the manufacturing of dyes and pigments. The compound has a wide range of industrial and pharmaceutical uses due to its versatile chemical properties and reactivity.

InChI:InChI=1/C5H8N2O2/c1-7-3-2-4(8)6-5(7)9/h2-3H2,1H3,(H,6,8,9)

Upstream product

• 615-77-0 1-methyluracil 
• 2213-08-3 ethyl 3-methylaminopropionate 
• 1408064-50-5 methyl 3-(N-methylcyanamido)propanoate 
• 119740-95-3 methyl 3-(N-tert-butoxycarbonyl-N-methyl)-aminopropionate 
• 54434-24-1 N-methyl,N-(β-cyanoethyl)-cyanamide 
• 72054-55-8 3-(1-methylureido)-propanoic acid 
• 24549-12-0 methyl 3-(methylamino)propanoate 

Downstream Products

• 6306-81-6 1-Methyl-5-brom-5.6-dihydro-uracil 
• 156918-68-2 3-(10-Undecenyl)-1-methylhydrouracil 

Relevant articles and documents

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Dibutylphosphate (DBP) mediated synthesis of cyclic N,N′- disubstituted urea derivatives from amino esters: A comparative study

The N,N′-disubstituted urea derivatives such as amino acid hydantoins and dihydrouracil derivatives were prepared starting from natural and unnatural amino acid esters using dibutylphosphate (DBP). During the attempted synthesis of N-heterocycles with larger than six-membered rings containing the N,N′-disubstituted urea functionalities, three unexpected products namely squamolone, N-methyl pyrrolidine-2-one, and diketopiperazine were isolated.

DIHYDROURACIL COMPOUNDS AS ANTI-ICTOGENIC OR ANTI-EPILEPTOGENIC AGENTS

Methods and compounds useful for the inhibition of convulsive disorders, including epilepsy, are disclosed. The methods and compounds of the invention inhibit or prevent or treat ictogenesis, epileptogenesis, or epileptogenesis-associated conditions. Methods for preparing the compounds of the invention are also described. Particularly preferred compounds of the invention include Formula 1 as described herein.