119740-95-3

Basic information

• Product Name: Methyl 3-((tert-butoxycarbonyl)(methyl)amino)propanoate
• Synonyms: Methyl 3-((tert-butoxycarbonyl)(methyl)amino)propanoate;tert-butyl 2-(methoxycarbonyl)ethylmethylcarbamate
• CAS NO: 119740-95-3
• Molecular Formula: C₁₀H₁₉NO₄
• Molecular Weight: 217.26216
• EINECS: -0
• Mol File: 119740-95-3.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 275.6±19.0 °C(Predicted)
• Appearance: /
• Density: 1.045±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: -1.52±0.70(Predicted)
• CAS DataBase Reference: Methyl 3-((tert-butoxycarbonyl)(methyl)amino)propanoate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 3-((tert-butoxycarbonyl)(methyl)amino)propanoate(119740-95-3)
• EPA Substance Registry System: Methyl 3-((tert-butoxycarbonyl)(methyl)amino)propanoate(119740-95-3)

Safety Data

• Hazardous Substances Data: 119740-95-3(Hazardous Substances Data)

Usage

General Description

Methyl 3-((tert-butoxycarbonyl)(methyl)amino)propanoate is a chemical compound with the molecular formula C11H21NO4. It is a derivative of propanoic acid and contains a tert-butoxycarbonyl group attached to a methylamino group. Methyl 3-((tert-butoxycarbonyl)(methyl)amino)propanoate is often used as a reagent in organic synthesis, particularly in the preparation of various pharmaceuticals and agrochemicals. Its properties make it useful for protecting the amine functional group in organic reactions, and it can also act as a chiral auxiliary in asymmetric synthesis. Methyl 3-((tert-butoxycarbonyl)(methyl)amino)propanoate is a valuable intermediate in the pharmaceutical and chemical industries, where it is used in the synthesis of a wide range of important compounds.

Upstream product

• 24549-12-0 methyl 3-(methylamino)propanoate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 67-56-1 methanol 
• 124072-61-3 N-t-butoxycarbonyl-N-methyl-β-alanine 
• 42116-55-2 methyl 3-tert-butoxycarbonylaminopropionate 
• 74-88-4 methyl iodide 
• 513-44-0 2-methylpropanethiol-1 
• 273756-96-0 methanesulfonic acid 2-(tert-butoxycarbonyl-methyl-amino)propyl ester 
• 3303-84-2 3-(tert-butyloxycarbonylamino)propionic acid 

Downstream Products

• 188952-73-0 Boc-Tyr-D-MetO-Phe-MeβAla-OMe 
• 696-11-7 1-methyl-dihydro-pyrimidine-2,4-dione 
• 1426943-70-5 ethyl 5-[(tert-butoxycarbonyl)(methyl)amino]-3-[(4-methoxyphenyl)amino]pent-2-enoate 
• 1426943-69-2 ethyl 5-[(tert-butoxycarbonyl)(methyl)amino]-3-(p-tolylamino)pent-2-enoate 
• 124072-61-3 N-t-butoxycarbonyl-N-methyl-β-alanine 
• 119740-91-9 (E)-3-(1-Benzoyl-1,2,2a,3-tetrahydro-benzo[cd]indol-5-yl)-2-[(tert-butoxycarbonyl-methyl-amino)-methyl]-acrylic acid methyl ester 
• 156263-72-8 (Z)-2-[({(E)-2-[3-(Acetyl-allyl-amino)-2-bromo-phenyl]-vinyl}-methyl-amino)-methyl]-3-phenylsulfanyl-acrylic acid methyl ester 
• 156263-70-6 methyl (Z)-2-(N-methyl)aminomethyl-3-phenylthio-2-propenoate 
• 65103-50-6 methyl 3-(N-methylamino)propionate hydrochloride 
• 868990-44-7 3-[benzyl-(1-phenyl-ethyl)-amino]-5-(tert-butoxycarbonyl-methyl-amino)-pentanoic acid tert-butyl ester 
• 868990-46-9 3-benzyloxycarbonylamino-5-(tert-butoxycarbonyl-methyl-amino)-pentanoic acid tert-butyl ester 
• 98642-44-5 tert-butyl (3-hydroxypropyl)methylcarbamate 

Relevant articles and documents

FLUOROMETHYL-SUBSTITUTED PYRROLE CARBOXAMIDES

The invention relates to pyrrole carboxamides bearing a fluoromethyl-moiety as voltage gated calcium channel blockers, to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or disorders.

Constructions of tetrahydro-γ-carboline skeletons via intramolecular oxidative carbon-carbon bond formation of enamines

The synthetically and biologically important 4-methyl and 4-methoxy tetrahydro-γ-carboline compounds were readily synthesized in high yields from an aryl amine and a 5-amino-3-oxopentanoate derivative through a series of reactions of enamination, oxidative annulation, deprotection/lactamization and the final reduction reaction of the carbonyl group. The underpinning strategy involves the oxidative C(sp2)-C(sp2) bond formation realized by either Pd(OAc)2/Cu(OAc)2 or a hypervalent iodine reagent.

Dibutylphosphate (DBP) mediated synthesis of cyclic N,N′- disubstituted urea derivatives from amino esters: A comparative study

The N,N′-disubstituted urea derivatives such as amino acid hydantoins and dihydrouracil derivatives were prepared starting from natural and unnatural amino acid esters using dibutylphosphate (DBP). During the attempted synthesis of N-heterocycles with larger than six-membered rings containing the N,N′-disubstituted urea functionalities, three unexpected products namely squamolone, N-methyl pyrrolidine-2-one, and diketopiperazine were isolated.