119740-95-3

Usage

Uses

Used in Organic Synthesis:
Methyl 3-((tert-butoxycarbonyl)(methyl)amino)propanoate is used as a reagent in organic synthesis for its ability to protect the amine functional group, which is crucial in the preparation of various pharmaceuticals and agrochemicals.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, Methyl 3-((tert-butoxycarbonyl)(methyl)amino)propanoate is used as an intermediate in the synthesis of a wide range of important compounds, contributing to the development of new drugs and therapeutic agents.
Used in Agrochemical Industry:
Similarly, in the agrochemical industry, Methyl 3-((tert-butoxycarbonyl)(methyl)amino)propanoate is utilized as an intermediate for the synthesis of various agrochemicals, playing a role in the production of pesticides and other agricultural chemicals.
Used as a Chiral Auxiliary:
Methyl 3-((tert-butoxycarbonyl)(methyl)amino)propanoate is also used as a chiral auxiliary in asymmetric synthesis, which is vital for the production of enantiomerically pure compounds, important in various applications including pharmaceuticals where the stereochemistry of a molecule can significantly affect its biological activity.

Upstream product

• 24549-12-0 methyl 3-(methylamino)propanoate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 3303-84-2 3-(tert-butyloxycarbonylamino)propionic acid 
• 124072-61-3 N-t-butoxycarbonyl-N-methyl-β-alanine 
• 74-88-4 methyl iodide 
• 513-44-0 2-methylpropanethiol-1 
• 273756-96-0 methanesulfonic acid 2-(tert-butoxycarbonyl-methyl-amino)propyl ester 
• 42116-55-2 methyl 3-tert-butoxycarbonylaminopropionate 
• 67-56-1 methanol 

Downstream Products

• 98642-44-5 tert-butyl (3-hydroxypropyl)methylcarbamate 
• 696-11-7 1-methyl-dihydro-pyrimidine-2,4-dione 
• 1426943-70-5 ethyl 5-[(tert-butoxycarbonyl)(methyl)amino]-3-[(4-methoxyphenyl)amino]pent-2-enoate 
• 1426943-69-2 ethyl 5-[(tert-butoxycarbonyl)(methyl)amino]-3-(p-tolylamino)pent-2-enoate 
• 124072-61-3 N-t-butoxycarbonyl-N-methyl-β-alanine 
• 119740-91-9 (E)-3-(1-Benzoyl-1,2,2a,3-tetrahydro-benzo[cd]indol-5-yl)-2-[(tert-butoxycarbonyl-methyl-amino)-methyl]-acrylic acid methyl ester 
• 156263-72-8 (Z)-2-[({(E)-2-[3-(Acetyl-allyl-amino)-2-bromo-phenyl]-vinyl}-methyl-amino)-methyl]-3-phenylsulfanyl-acrylic acid methyl ester 
• 156263-70-6 methyl (Z)-2-(N-methyl)aminomethyl-3-phenylthio-2-propenoate 
• 188952-73-0 Boc-Tyr-D-MetO-Phe-MeβAla-OMe 
• 868990-44-7 3-[benzyl-(1-phenyl-ethyl)-amino]-5-(tert-butoxycarbonyl-methyl-amino)-pentanoic acid tert-butyl ester 
• 868990-46-9 3-benzyloxycarbonylamino-5-(tert-butoxycarbonyl-methyl-amino)-pentanoic acid tert-butyl ester 
• 65103-50-6 methyl 3-(N-methylamino)propionate hydrochloride 

Relevant academic research and scientific papers

FLUOROMETHYL-SUBSTITUTED PYRROLE CARBOXAMIDES

The invention relates to pyrrole carboxamides bearing a fluoromethyl-moiety as voltage gated calcium channel blockers, to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or disorders.

FLUOROMETHYL-SUBSTITUTED PYRROLE CARBOXAMIDES

The invention relates to pyrrole carboxamides bearing a fluoromethyl- moiety as voltage gated calcium channel blockers, to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or disorders.

Constructions of tetrahydro-γ-carboline skeletons via intramolecular oxidative carbon-carbon bond formation of enamines

The synthetically and biologically important 4-methyl and 4-methoxy tetrahydro-γ-carboline compounds were readily synthesized in high yields from an aryl amine and a 5-amino-3-oxopentanoate derivative through a series of reactions of enamination, oxidative annulation, deprotection/lactamization and the final reduction reaction of the carbonyl group. The underpinning strategy involves the oxidative C(sp2)-C(sp2) bond formation realized by either Pd(OAc)2/Cu(OAc)2 or a hypervalent iodine reagent.

1,3,4-OXADIAZOLE AND 1,3,4-THIADIAZOLE BETA-LACTAMASE INHIBITORS

β-Lactamase inhibitor compounds (BLIs) are disclosed, including compounds that have activity against class A, class C or class D β-lactamases. Methods of manufacturing the BLIs, and uses of the compounds in the preparation of pharmaceutical compositions and antibacterial applications are also disclosed.

Dibutylphosphate (DBP) mediated synthesis of cyclic N,N′- disubstituted urea derivatives from amino esters: A comparative study

The N,N′-disubstituted urea derivatives such as amino acid hydantoins and dihydrouracil derivatives were prepared starting from natural and unnatural amino acid esters using dibutylphosphate (DBP). During the attempted synthesis of N-heterocycles with larger than six-membered rings containing the N,N′-disubstituted urea functionalities, three unexpected products namely squamolone, N-methyl pyrrolidine-2-one, and diketopiperazine were isolated.

New approaches for the synthesis of isotopically labelled guanidine-derived amino acids and noradrenaline reuptake inhibitors

A new approach for the stereoselective synthesis of guanidine-derived amino acids, L-arginine and (+)-blastidic acid, has been devised which allows the selective incorporation of isotopic labels in both the side chain of the amino acid as well as the guanidine unit. A new asymmetric synthesis of the (S,R)-diastereomer of reboxetine, an antidepressant, has also been completed which allows the specific incorporation of radiolabelled iodine for SPECT imaging. Copyright

A highly efficient, asymmetric synthesis of blastidic acid: The β-amino acid component of the antibiotic, (+)-blasticidin S

A new approach for the asymmetric synthesis of blastidic acid, the β-amino acid component of the antibiotic, (+)-blasticidin S has been achieved in 11 steps and 30% overall yield. The key transformations involve a one-pot Swern/Wittig reaction sequence to

Synthesis and antinociceptive activity of orally active opioid peptides: Improvement of oral bioavailability by esterification

To improve the oral bioavailability of a dermorphin tetrapeptide analog, Nα-1-iminoethyl-Tyr-D-MetO-Phe-MeβAla-OH (III), 1) which has a potent analgesic activity after oral administration, various derivatives were synthesized to incr

Tandem radical cyclisations: Synthesis of lysergic acid derivatives

A novel free radical cyclisation approach for the synthesis of lysergic acid analogues has been investigated. The homolytic cleavage of carbon- bromine bond, mediated by tri-n-butyltin hydride, led to the development of a method for the construction of 3,

New Histidyl amino acid derivatives, and pharmaceutical composition comprising the same

A compound of the formula: STR1 wherein R1 is lower alkyl optionally substituted with a substituent selected from the group consisting of acyl, hydroxy, lower alkoxy, aryl, lower alkylthio and a group of the formula: STR2 in which R5 is hydrogen or acyl and R6 is hydrogen or lower alkyl; aryl; or amino optionally substituted with substituent(s) selected from the group consisting of lower alkyl and acyl; and R2 is hydrogen or lower alkyl; or R1 and R2 are taken together with the attached nitrogen atom to form a heterocyclic group optionally substituted with substituent(s) selected from the group consisting of lower alkyl, hydroxy(lower )alkyl, lower alkoxy(lower)alkyl, acyl(lower)alkyl, oxo and acyl; R3 is hydrogen or lower alkyl; and R4 is lower alkyl; and its pharmaceutically acceptable salt, processes for the preparation thereof and pharmaceutical composition comprising the same.