696-68-4Relevant articles and documents
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Washburn,W.N.
, p. 1615 - 1616 (1975)
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PTP-1B inhibitors: Cyclopenta[d][1,2]-oxazine derivatives
Cho, Sung Yun,Baek, Ji Yoen,Han, Sang Sub,Kang, Seung Kyu,Ha, Jae Du,Ahn, Jin Hee,Lee, Jae Don,Kim, Kwang Rok,Cheon, Hyae Gyeong,Rhee, Sang Dal,Yang, Sung Don,Yon, Gyu Hwan,Pak, Chwang Siek,Choi, Joong-Kwon
, p. 499 - 502 (2007/10/03)
A series of novel cyclopenta[d][1,2]-oxazine derivatives was prepared and evaluated for their inhibitory activity toward protein tyrosine phosphatase 1B (PTP-1B). Compound 6s was found to be an inhibitor of PTP-1B with nanomolar IC50 value and
Tautomerism in the solid state and in solution of a series of 6-aminofulvene-1-aldimines
Sanz, Dionisia,Perez-Torralba, Marta,Alarcon, Sergio Hugo,Claramunt, Rosa Maria,Foces-Foces, Concepcion,Elguero, Jose
, p. 1462 - 1471 (2007/10/03)
To study systems able to sustain intramolecular proton-transfer, we have prepared a series of six aminofulvene aldimines including several labeled with 15N and 2H. These compounds show coupling constants through the hydrogen bond, 1hJ(15N-1H) and 2hJ(15N-15N). The position of the tautomeric equilibria, i.e., on what nitrogen atom is the proton, was determined in the solid state and in solution. The crystal structure of N{([5-[(phenylamino)methylene]- 1,3-cyclopentadien-1-yl]methylene})pyrrole-1-amine (3) has been determined by X-ray analysis. In solution, both N-H and C-H tautomers were observed and their structures assigned by NMR spectroscopy. Particularly useful is the value of the 1J(15N-1H) coupling constant.
