69614-95-5

Usage

Uses

Used in Pharmaceutical Industry:
4-(2-CHLOROETHYL)ACETOPHENONE is used as a synthetic intermediate for the production of various pharmaceuticals and organic compounds. Its unique chemical structure allows it to be a key component in the synthesis of certain drugs, contributing to their therapeutic properties.
Used in Chemical Research:
In the field of chemical research, 4-(2-CHLOROETHYL)ACETOPHENONE serves as a valuable compound for studying its potential applications and understanding its chemical behavior. Researchers can use 4-(2-CHLOROETHYL)ACETOPHENONE to explore its reactivity, stability, and interactions with other molecules, which can lead to the development of new chemical processes and products.
Used in Environmental and Safety Regulations:
Due to its potential carcinogenic and mutagenic properties, 4-(2-CHLOROETHYL)ACETOPHENONE is subject to various environmental and safety regulations. It is important for regulatory agencies to monitor and control the use of this chemical to minimize its potential harm to human health and the environment.
Used in Safety Training and Protocols:
To ensure the safe handling and use of 4-(2-CHLOROETHYL)ACETOPHENONE, safety training and protocols are essential. Workers and researchers should be educated on the potential risks associated with this chemical and be provided with appropriate safety measures, such as personal protective equipment and proper disposal methods, to minimize exposure and prevent accidents.

InChI:InChI=1/C10H11ClO/c1-8(12)10-4-2-9(3-5-10)6-7-11/h2-5H,6-7H2,1H3

Upstream product

• 622-24-2 2-phenylethyl chloride 
• 75-36-5 acetyl chloride 
• 107-06-2 1,2-dichloro-ethane 
• 149104-90-5 4-acetylphenylboronic acid 
• 107-04-0 1-Bromo-2-chloroethane 

Downstream Products

• 69614-96-6 2-Bromo-1-[4-(2-chloro-ethyl)-phenyl]-ethanone 
• 117922-92-6 4-(2-chloroethyl)acetophenone (p-tolylsulfonyl)hydrazone 
• 115665-94-6 (E)-4-(4-acetylphenyl)but-3-en-2-one 
• 117922-88-0 4-(4-(2-Chloroethyl)phenyl)-thiazol-2-one 
• 117922-94-8 4-<4-(2-chloroethyl)phenyl>-2-aminothiazole hydrobromide 
• 117922-88-0 4-<4-(2-chloroethyl)phenyl>thiazol-2-one 
• 1160521-43-6 (6aR,9aS)-5,6a,7,8,9,9a-hexahydro-1-(4-acetylphenethyl)-5-methyl-3-phenylaminocyclopent[4,5]imidazo[1,2-a]pyrazolo[4,3-e]pyrimidin-4(1H)-one 
• 1101866-43-6 1-[4-(2-choroethyl)phenyl]-2-(6-nitro-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidin-7-yl)ethanone 
• 10537-63-0 1-(4-vinylphenyl)ethanone 

Relevant academic research and scientific papers

Selective activation of 1,2-dichloroethane for access to β-chloroethylarenes enabled by nickel-catalyzed suzuki-type couplings

The selective conversion of one inactive C(sp3)-Cl bond of 1,2-dichloroethane (DCE) into C(sp3)-C(sp2) linkages for access to β-chloroethylarenes is presented here. The key to achieve the required reactivity and chemoselectivity in this synthetic method was the utilization of nickel and combinatorial nitrogen ligands as catalytic system. Synthetic advantages of this coupling chemistry included the step-simplicities to β-chloroethylarenes, the mildness and effectiveness of coupling conditions, together with the convenience for allowing further functional group transformations of the retained homobenzylic C–Cl bonds.

Preparation method of chloroethyl-substituted aromatic compound

The invention belongs to the technical field of preparation of organic chloride products and particularly relates to a preparation method of a beta-chloroethyl-substituted aromatic compound. The method comprises the following steps: by taking 1-bromine-2-chloroethane and arylboronic acid as raw materials in the atmosphere of a reaction solution and nitrogen gas, heating under the action of a catalytic system with a nickel catalyst and a dipyridyl ligand, and weak base additives and pyridine additives, separating and purifying after reaching a reaction endpoint to obtain the beta-chloroethyl-substituted aromatic compound. According to the preparation method, the nickel catalyst and the dipyridyl ligand which are cheap and easily available are commercially available are used as the catalyticsystem; the directional introduction from beta-chloroethyl to aromatic group is achieved, so that the beta-chloroethyl-substituted aromatic compound can be efficiently prepared. The method is mild inreaction condition and low in raw material cost; the reaction steps are simple and are easy to operate; meanwhile, the reaction scale is easy to enlarge; the product is simple and convenient to separate; the method is suitable for industrial production.

Arylpiperazinyl-alkylene-phenyl-heterocyclic compounds

Arylpiperazinyl-alkylenephenyl-p-heterocyclic compounds, and the pharmaceutically acceptable acid addition salts thereof are neuroleptic agents. They are useful in the treatment of psychotic disorders.

Arylpiperazinyl-alkylene-phenyl-heterocyclic compounds

An arylpiperazinyl-alkylenephenyl-p-heterocyclic compound, useful in the treatment of psychotic disorders, of the formula- or a pharmaceutically-acceptable acid-addition salt thereof,wherein:-, Ar is phenyl, 3-trifluoromethylphenyl, 3-cyanopyridyl, naphth