6962-03-4Relevant articles and documents
Synthesis, antiproliferative and antibacterial evaluation of C-ring modified colchicine analogues
Huczyński, Adam,Rutkowski, Jacek,Popiel, Katarzyna,Maj, Ewa,Wietrzyk, Joanna,Stefańska, Joanna,Majcher, Urszula,Bartl, Franz
, p. 296 - 301 (2015)
A series of 10 amine derivatives of colchicine have been obtained with high yields by modification at C(10)-OCH3position of C-ring and characterized by spectroscopic methods. In vitro cytotoxicity has been evaluated against four human tumour ce
Synthesis and antitumour activity of novel colchicine C-10 derivatives
Shen, Li Hong,Zhang, Le,Wang, Hai Xian,Wang, Xin,Zhang, Gai Jiao
, p. 7475 - 7476 (2015/04/22)
A series of new colchicine C-10 derivatives (2a-i, 3a-h) were synthesized by replacement of the 10-methoxy with NR2 and SCH3 in order to determine their cytotoxic activity. The compounds were synthesized in good yield and the structures of all newly synthesized compounds were established on the basis of their IR, 1H NMR and elemental analysis. The synthesized compounds were tested in vitro antitumor activity against four human cancer cell lines by MTT assay. It was found that many of the derivatives displayed significant activity, particularly, compound 2a and 2b showed more potent cytotoxic activities than colchicine.
