69625-62-3

Basic information

• Product Name: 1-(tricyclo[3.3.1.1~3,7~]dec-1-yl)-1H-1,2,4-triazole
• Synonyms: 1-(Adamantan-1-yl)-1H-1,2,4-triazole; 1-Adamantan-1-yl-1H-[1,2,4]triazole; 1H-1,2,4-Triazole, 1-tricyclo[3.3.1.1~3,7~]dec-1-yl-
• CAS NO: 69625-62-3
• Molecular Formula: C₁₂H₁₇N₃
• Molecular Weight: 203.2835
• Mol File: 69625-62-3.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 344.4°C at 760 mmHg
• Flash Point: 162.1°C
• Density: 1.48g/cm³
• Vapor Pressure: 6.59E-05mmHg at 25°C
• Refractive Index: 1.791
• CAS DataBase Reference: 1-(tricyclo[3.3.1.1~3,7~]dec-1-yl)-1H-1,2,4-triazole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(tricyclo[3.3.1.1~3,7~]dec-1-yl)-1H-1,2,4-triazole(69625-62-3)
• EPA Substance Registry System: 1-(tricyclo[3.3.1.1~3,7~]dec-1-yl)-1H-1,2,4-triazole(69625-62-3)

Safety Data

• Hazardous Substances Data: 69625-62-3(Hazardous Substances Data)

Usage

Type of compound

Heterocyclic compound

Structure

Contains a tricyclic decane ring system

Derivative of

1,2,4-triazole

Potential applications

Medicinal chemistry and pharmaceutical research

Biological target modulation

Enzymes and receptors

Pharmacological properties

Unique properties that may be useful in the development of new therapeutic agents

Further research needed

To fully understand its biological and pharmacological properties

Upstream product

• 768-95-6 1-adamanthanol 
• 288-88-0 1,2,4-Triazole 
• 612058-38-5 (1-adamantyloxy)di(phenyl)phosphine 
• 281-23-2 adamantane 
• 290-87-9 1,3,5-Triazine 
• 16782-39-1 1-adamantylhydrazine hydrochloride 
• 935-56-8 1-chloroadamantane 
• 768-90-1 1-Adamantyl bromide 

Relevant articles and documents

Alkylphosphinites as Synthons for Stabilized Carbocations

We present a new acid-free method for the generation of carbocations based on a redox condensation reaction that enables SN1 reactions with a variety of nucleophiles. We utilize readily synthesized phosphinites that are activated by diisopropyl azodicarboxylate to form betaine structures that collapse upon adding a pronucleophile, thereby yielding reactive carbocation intermediates. We also employ this approach for the alkylation of some bioactive molecules.

Solvent-free and direct C(sp3)-H amination of adamantanes by grinding

A facile, direct and environmentally benign conversion of C(sp 3)-H bonds to C(sp3)-N bonds using substoichiometric amount of aprotic superelectrophiles polyhalomethane-AlX3 has been achieved by grinding under solvent-free

Adamantylazoles. Acid-catalyzed adamantylation of 1,2,4-triazoles

The reaction of 1-adamantanol with 1,2,4-triazole in sulfuric acid forms 1-adamantyl derivatives. In boiling chloroform containing traces of sulfuric acid, a mixture of isomeric N-adamantyl-1,2,4-triazoles is obtained. It is shown that 1-adamantyl carbocation is formed at a sulfuric acid concentration above 70%. 1997 Plenum Publishing Corporation.