69629-62-5Relevant academic research and scientific papers
Dihydrobenzisoxazole-4-one compounds are novel selective inhibitors of aldosterone synthase (CYP11B2) with in vivo activity
Meyers, Kenneth,Cogan, Derek A.,Burke, Jennifer,Arenas, Raquel,Balestra, Michael,Brown, Nicholas F.,Chen, Zhidong,Cerny, Matthew A.,Clifford, Holly E.,Colombo, Federico,Fader, Lee,Frederick, Kosea S.,Guo, Xin,Goldberg, Daniel,Hornberger, Keith R.,Kugler, Stanley,Lord, John,Marshall, Daniel R.,Moss, Neil,Parmentier, Jean-Huges,Richman, Jeremy R.,Schmenk, Jennifer,Weldon, Steven M.,Yu, Maolin,Zhang, Michael
, p. 979 - 984 (2018)
6,7-Dihydro-5H-2,1-benzisoxazol-4-one analogs are potent inhibitors of aldosterone synthase (CYP11B2) with selectivity over the highly homologous enzyme cortisol synthase (CYP11B1). These compounds are unique among inhibitors of CYP11B2 in their lack of a
Gold-Catalyzed Photoredox C(sp2) Cyclization: Formal Synthesis of (±)-Triptolide
Cannillo, Alexandre,Schwantje, Travis R.,Bégin, Maxime,Barabé, Francis,Barriault, Louis
supporting information, p. 2592 - 2595 (2016/07/06)
Photoexcitation of a dimeric gold complex showed the activation of a C(sp2)-Br bond to generate a vinyl radical in a mild photoredox catalysis process. Use of [Au2(dppm)2]Cl2 with 365 nm LEDs in a photoredox catalysis process to produce polycyclic scaffolds using vinyl radicals is reported. This method achieved the synthesis of a small library of butenolide polycyclic compounds and naphthol polycyclic compounds. The efficacy of this photoredox process was further demonstrated by accomplishing the concise formal synthesis of (±)-triptolide.
