Dihydrobenzisoxazole-4-one compounds are novel selective inhibitors of aldosterone synthase (CYP11B2) with in vivo activity

Article abstract of DOI:10.1016/j.bmcl.2017.12.015

6,7-Dihydro-5H-2,1-benzisoxazol-4-one analogs are potent inhibitors of aldosterone synthase (CYP11B2) with selectivity over the highly homologous enzyme cortisol synthase (CYP11B1). These compounds are unique among inhibitors of CYP11B2 in their lack of a

Full text of DOI:10.1016/j.bmcl.2017.12.015

Accepted Manuscript
Dihydrobenzisoxazole-4-one compounds are novel selective inhibitors of al-
dosterone synthase (CYP11B2) with in vivo activity
Kenneth Meyers, Derek A. Cogan, Jennifer Burke, Raquel Arenas, Michael
Balestra, Nicholas F. Brown, Matthew A. Cerny, Holly E. Clifford, Federico
Colombo, Lee Fader, Kosea S. Frederick, Xin Guo, Keith R. Hornberger,
Stanley Kugler, John Lord, Daniel R. Marshall, Neil Moss, Jeremy R. Richman,
Jennifer Schmenk, Steven M. Weldon, Maolin Yu, Michael Zhang, Zhidong
Chen
PII:
S0960-894X(17)31175-7
https://doi.org/10.1016/j.bmcl.2017.12.015
BMCL 25471
DOI:
Reference:
Bioorganic & Medicinal Chemistry Letters
To appear in:
Received Date:
Revised Date:
Accepted Date:
28 March 2017
6 December 2017
7 December 2017
Please cite this article as: Meyers, K., Cogan, D.A., Burke, J., Arenas, R., Balestra, M., Brown, N.F., Cerny, M.A.,
Clifford, H.E., Colombo, F., Fader, L., Frederick, K.S., Guo, X., Hornberger, K.R., Kugler, S., Lord, J., Marshall,
D.R., Moss, N., Richman, J.R., Schmenk, J., Weldon, S.M., Yu, M., Zhang, M., Chen, Z., Dihydrobenzisoxazole-4-
one compounds are novel selective inhibitors of aldosterone synthase (CYP11B2) with in vivo activity, Bioorganic
& Medicinal Chemistry Letters (2017), doi: https://doi.org/10.1016/j.bmcl.2017.12.015
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