69638-07-9Relevant academic research and scientific papers
Controlled Release of Salicylic Acid from Biodegradable Cross-Linked Polyesters
Dasgupta, Queeny,Chatterjee, Kaushik,Madras, Giridhar
, p. 3479 - 3489 (2015)
The purpose of this work was to develop a family of cross-linked poly(xylitol adipate salicylate)s with a wide range of tunable release properties for delivering pharmacologically active salicylic acid. The synthesis parameters and release conditions were
PROCESS AND INTERMEDIATES FOR PREPARING POLY(ANHYDRIDE-ESTERS)
-
Paragraph 0094; 0095; 0096; 0097, (2017/05/19)
Certain embodiments of the invention provide a method comprising treating a hydroxy-carboxylic acid compound with a compound of formula (I) in the absence of a solvent, to provide a diacid of formula (II), wherein R is a linker molecule; wherein each Y is
ACTIVE AGENTS AND THEIR OLIGOMERS AND POLYMERS
-
Page/Page column 30, (2008/06/13)
Conjugates comprising at least two active agents linked by a diglycolic acid or polyglycol diacid linker are disclosed. The invention also concerns oligomers and polymers of these conjugates and their use in therapeutic and industrial applications for loc
Low-energy collision-induced fragmentation of negative ions derived from diesters of aliphatic dicarboxylic acids made with hydroxybenzoic acids
Nishshanka, Upul,Attygalle, Athula B.
experimental part, p. 1502 - 1511 (2009/10/10)
Diesters of ortho-hydroxybenzoic acid (salicylic acid) made with glutaric, adipic, and pimelic acids are the monomers of some potential drug candidates for aspirin patches. Collision-induced dissociation (CID) spectra of negative ion derived from these compounds show a 120-Da 'neutral loss' specific to the ortho isomers. In contrast, the anions derived from diesters of meta- and para-hydroxybenzoic acids show a 138-Da loss for an elimination of elements of hydroxybenzoic acid by a charge-remote mechanism. Deuterium labeling studies confirmed that the hydrogen atom transferred for hydroxybenzoic acid loss originates specifically from the α position of the dicarboxylic acid moiety. Although all spectra showed a peak at m/z 137, a charge-mediated process specific for the ortho compounds renders it the most prominent peak in the spectra of ortho compounds. Appropriate deuterium labeling experiments demonstrated that the hydrogen atom transferred for the formation of the m/z 137 ion in ortho compounds is specifically derived from the α position of the dicarboxylic acid moiety. Copyright
Effect of linker structure on salicylic acid-derived poly (anhydride - Esters)
Prudencio, Almudena,Schmeltzer, Robert C.,Uhrich, Kathryn E.
, p. 6895 - 6901 (2007/10/03)
A series of salicylic acid-derived poly(anhydride-esters) were synthesized by melt polymerization methods, in which the structures of the molecule ("linker") linking together the two salicylic acids were varied. To determine the relationship between the l
