69639-47-0

Usage

InChI:InChI=1/C34H61N5O9/c1-9-11-12-13-14-15-16-26(43)23(6)33(48)39(8)34(20-41,17-21(3)4)27(44)18-36-32(47)29(24(7)42)38-30(45)25(19-40)37-31(46)28(35)22(5)10-2/h20-22,24-26,28-29,40,42-43H,6,9-19,35H2,1-5,7-8H3,(H,36,47)(H,37,46)(H,38,45)/t22-,24+,25+,26-,28+,29+,34-/m1/s1

Upstream product

• 540482-20-0 O'TBS-OBn-globomycin 
• 308279-80-3 O-benzyl globomycin 
• 540482-14-2 (2R,3R)-3-[Boc-L-allo-Thr(TBS)-GlyO]-2-methyl-undecanoyl-N-methyl-L-Leu-L-allo-Ile-L-Ser(Bn)OAllyl 
• 540482-15-3 (2R,3R)-3-(Boc-L-allo-Thr-GlyO)-2-methyl-undecanoyl-N-methyl-L-Leu-L-allo-Ile-L-Ser(Bn)OAllyl 
• 540482-16-4 (2R,3R)-3-(Boc-L-allo-Thr-GlyO)-2-methyl-undecanoyl-N-methyl-L-Leu-L-allo-Ile-L-Ser(Bn)OH 
• 540482-13-1 (2R,3R)-3-hydroxy-2-methyl-undecanoyl-N-methyl-L-Leu-L-allo-Ile-L-Ser(Bn)OAllyl 
• 540482-11-9 (2R,3R)-3-Hydroxy-2-methyl-undecanoic acid (1R,2S)-2-[benzyl-(2,4,6-trimethyl-benzenesulfonyl)-amino]-1-phenyl-propyl ester 
• 540482-12-0 (2R,3R)-3-hydroxy-2-methylundecanoic acid 
• 308279-70-1 N-methyl-L-leucine-L-allo-isoleucine-O-benzyl-L-serine allyl ester 
• 124-19-6 nonan-1-al 
• 540482-17-5 OBn-SF-1902 A₅ 

Relevant academic research and scientific papers

Solid phase synthesis of globomycin and SF-1902 A5

The syntheses of the natural lipocyclodepsipeptide-type antibiotics globomycin and SF-1902 A5 are reported, utilizing solid phase technology for the construction of the peptidic fragment and a new asymmetric methodology of epoxidation for the p

Total synthesis and NMR conformational study of signal peptidase II inhibitors, globomycin and SF-1902 A5

A stereoselective total synthesis of an antibiotic, globomycin (1a), and its congener, SF-1902 A5 (1b), was achieved. Two convergent macrocyclization routes via macrolactamization or macrolactonization to form 1a are described. A conformational study by means of NMR spectroscopy was performed in several solvents. The 1H NMR spectrum of 1a indicated that the amide proton of only the L-allo-Thr residue was involved in the hydrogen bonding. The structure in solution phase was different from the X-ray structure.