6964-26-7Relevant academic research and scientific papers
2-Cycloalkyl phenoxyacetic acid CRTh2 receptor antagonists
Sandham, David A.,Aldcroft, Clive,Baettig, Urs,Barker, Lucy,Beer, David,Bhalay, Gurdip,Brown, Zarin,Dubois, Gerald,Budd, David,Bidlake, Louise,Campbell, Emma,Cox, Brian,Everatt, Brian,Harrison, David,Leblanc, Catherine J.,Manini, Jodie,Profit, Rachael,Stringer, Rowan,Thompson, Katy S.,Turner, Katharine L.,Tweed, Morris F.,Walker, Christoph,Watson, Simon J.,Whitebread, Steven,Willis, Jennifer,Williams, Gareth,Wilson, Caroline
, p. 4347 - 4350 (2008/12/20)
High throughput screening identified a phenoxyacetic acid scaffold as a novel CRTh2 receptor antagonist chemotype, which could be optimised to furnish a compound with functional potency for inhibition of human eosinophil shape change and oral bioavailability in the rat.
Photoelectron transfer induced decarboxylation of substituted carboxylic acids across a liquid/liquid interface
Rajesh,Thanulingam,Das, Suresh
, p. 16817 - 16834 (2007/10/03)
Methylene blue photocatalyzed electron transfer reactions of some phenoxyacetic acid derivatives and N-phenylglycine across a liquid/liquid interface led to their efficient decarboxylation. Nanosecond laser flash photolysis studies of this process, in a reverse micellar system of Aerosol- OT (AOT)-benzene-water indicated that the liquid/liquid interface acts as a barrier in controlling the energy wasting back electron transfer. Intramolecular C-C bond forming reactions of these radicals were utilized for the synthesis of various chroman derivatives.
