6964-95-0

Usage

Heterocyclic Rings

Pyridine ring and pyrimidine ring
Backbone: Tetrahydropyridine
Functional Group: Substituted pyrimidinone

Synthetic Importance

Intermediate: Crucial in the synthesis of various pharmaceuticals and bioactive compounds

Biological Activity

Interaction: Ability to interact with biological targets
Potential Applications: Drug discovery and development

Significance

Medicinal Chemistry: Valuable compound in medicinal chemistry research

Research Interest

Organic Chemistry: Subject of study due to its unique structure and properties

Upstream product

• 50-01-1 guanidine hydrochloride 
• 3731-15-5 2-ethoxy-3,4,5,6-tetrahydropyridine-3-carboxylic acid ethyl ester 
• 3731-16-6 3-carboethoxy-2-pyridone 

Downstream Products

• 1612180-72-9 4-(2,3-dimethylphenyl)-5H,6H,7H,8H-pyrido[2,3-d]pyrimidin-2-amine 
• 1612180-73-0 4-(2,3-dichlorophenyl)-5H,6H,7H,8H-pyrido[2,3-d]pyrimidin-2-amine 
• 1612180-74-1 4-[1-(benzenesulfonyl)-1H-indol-3-yl]-5H,6H,7H,8H-pyrido[2,3-d]pyrimidin-2-amine 

Relevant academic research and scientific papers

PYRIMIDINE DERIVATIVES FOR USE IN THE TREATMENT OF CANCER

Compounds of Formula I or II in which R1, X1 and X2 have the meanings indicated in claim 1, are MTH1 inhibitors and can be employed, inter alia, in the treatment of cancer.

MTH1 INHIBITORS FOR TREATMENT OF INFLAMMATORY AND AUTOIMMUNE CONDITIONS

A compound of formula (I), or a pharmaceutically acceptable salt thereof, for use in the treatment of autoimmune diseases and inflammatory conditions.

Direct synthesis of 5- and 6-substituted 2-aminopyrimidines as potential non-natural nucleobase analogues

A series of 2-aminopyrimidine derivatives, substituted at 5- and 6-positions, were synthesized. The reaction was carried out in a single step by treatment of the corresponding β-ketoester or β-aldehydoester with guanidine hydrochloride in the presence of K2CO3, in a microwave-assisted method without the requirement of solvent. A unique 1:1 co-crystal structure was obtained which shows that a 6-phenyl-2- aminopyrimidinone forms a strong nucleobase-pair with cytosine, involving three hydrogen bonds. The base-pair was found to be as strong as that of natural guanine:cytosine (G:C), signifying the potential application of the synthesized derivatives. Additionally, we also report a second co-crystal involving 5-isopropyl-6-methyl-2-aminopyrimidinone and cytosine in a 1:1 ratio, which also shows strong base-pairing properties. the Partner Organisations 2014.