69640-06-8

Upstream product

• 121789-42-2 1-(5-Brom-2-methoxyphenyl)-1,4-butandion 
• 2476-35-9 5-bromo-2-methoxybenzoic acid 
• 121789-30-8 1-(5-Brom-2-methoxyphenyl)-3-(1,3-dioxan-2-yl)-propanon 
• 25016-01-7 5-bromo-2-methoxybenzaldehyde 
• 62910-63-8 5-bromo-2-methoxybenzoyl chloride 

Downstream Products

• 69640-36-4 2,3,4-Tribrom-5-(5-brom-2-methoxyphenyl)-1H-pyrrol 
• 121789-64-8 2,3,4-Tribrom-5-(5-brom-2-hydroxyphenyl)-1H-pyrrol 

Relevant academic research and scientific papers

Marine Bacteria, I. - Synthesis of Pentabromopseudiline, a Cytotoxic Phenylpyrrole from Alteromonas luteo-violaceus

A new synthesis of 2,3,4-tribromo-5-(3,5-dibromo-2-hydroxyphenyl)pyrrole (1a, pentabromopseudiline), an antibiotic, enzymeinhibitory and cytotoxic active constituent of the marine bacterium Alteromonas luteo-violaceus, is described.For investigation of structure-activity relationships further 2-phenylpyrroles are investigated.Key step in their synthesis is the Grignard reaction of 2-(1,3-dioxan-2-yl)ethylmagnesium bromide (9d) with benzoyl chlorides yielding γ-phenyl-γ-ketoaldehydes 24, and the Paal-Knorr cyclisation of the latter. - Key Words: Alteromonas luteo-violaceus / Bromopyrrole / Marine bacteria / Pentabromopseudiline