69640-38-6

Upstream product

• 69640-34-2 2,3,4-trichloro-5-(3,5-dichloro-2-methoxyphenyl)-1H-pyrrole 
• 527-62-8 2,4-dichloro-6-aminophenol 
• 121789-62-6 2-(3,5-Dichlor-2-hydroxyphenyl)-1H-pyrrol 
• 76008-04-3 3,5-dichloro-2-methoxybenzaldehyde 
• 1198777-66-0 2-(3,5-dichloro-2-methoxyphenyl)-1-(p-tolylsulfonyl)-2,3-dihydro-1H-pyrrole 
• 1198777-63-7 N-[1-(3,5-dichloro-2-methoxyphenyl)-but-3-ynyl]-4-methylbenzene-sulfonamide 
• 1198777-59-1 N-[1-(3,5-dichloro-2-methoxyphenyl)-4-(trimethylsilyl)but-3-ynyl]-4-methylbenzenesulfonamide 
• 90-60-8 3,5-dichlorosalicyclaldehyde 
• 1198777-56-8 N-(3,5-dichloro-2-methoxybenzylidene)-4-methylbenzenesulfonamide 
• 69640-33-1 2-(3,5-dichloro-2-methoxyphenyl)-1H-pyrrole 

Relevant academic research and scientific papers

C–H Arylation of N-Heteroarenes under Metal-Free Conditions and its Application towards the Synthesis of Pentabromo- and Pentachloropseudilins

Herein, we are reporting metal-free conditions for radical initiation and direct C–H arylation of N-heteroarenes. Starting from aniline, the corresponding arenediazonium salt generated in situ is reduced to an aryl radical in the presence of chloropromazine hydrochloride, a new reagent for this application. The optimized procedures are mild, operationally simple, and are working successfully with more diverse substrates in comparison to reported methods. The optimized method is also employed for the synthesis of marine natural products Pentabromo- and Pentachloropseudilins (PBP/PCP). In the present study, we also validated the potential of the Pentachloropseudilin (PCP), thus synthesized, for inhibition of Myosin1 function in mammalian cells and confirmed that PCP phenocopies Myosin1c depletion in cells.

Silver(I)-catalyzed route to pyrroles: Synthesis of halogenated pseudilins as allosteric inhibitors for myosin atpase and x-ray crystal structures of the protein-inhibitor complexes

The pentahalogenated 2-arylpyrrole-type alkaloids pentabromopseudilin and pentachloropseudilin represent a new class of isoform-specific allosteric inhibitors of myosin ATPase. Herein, we describe an application of the silver(I)-catalyzed cycloisomerizati

MEANS FOR TREATING MYOSIN-RELATED DISEASES

The present invention provides a method of designing a modulator of a myosin, the method comprising molecular modeling of a compound such that the modeled compound interacts with at least three amino acid residues of said myosin, said residues being selec

Total synthesis of pentabromo- and pentachloropseudilin, and synthetic analogues-allosteric inhibitors of myosin ATPase

Stopping myo: The total syntheses of the title compounds have been achieved using a highly efficient silver(I)- catalyzed cyclization of N-tosyl-homopropargylamines. The pseudilin derivatives represent a novel class of myosin inhibitors. A new allosteric