6965-67-9

Upstream product

• 100-69-6 2-vinylpyridine 

Downstream Products

• 144157-46-0 N,N-bis(2-(pyridin-2-yl)ethyl)benzamide 

Relevant academic research and scientific papers

Effect of Chelate Ring Size of Binuclear Copper(II) Complexes on Catecholase Activity and DNA Cleavage

Catecholase activity of dicopper(II) complexes containing different numbers of chelate members in the pyridine groups of the ligand was studied to identify a functional model for copper enzyme catechol oxidase. Complexes [CuII(μ-OH)CuII/s

A new synthesis of bis(2-{pyrid-2-yl}ethyl)amine (LH) from bis(2-{pyrid-2-yl}ethyl)hydroxylamine (LOH), and the copper-dependent reduction of LOH to LH

Solutions of [CuCl2LOH], and other reaction mixtures containing LOH and Cu(II) or Cu(I) salts, degrade to yield dark green or brown residues containing the LH ligand. In contrast, [MCl2LOH] (M = Zn, Ni, Co) are indefinitely stable in solution and the solid state.

Unprecedented synthesis of symmetrical azines from alcohols and hydrazine hydrate using nickel based NNN-pincer catalyst: An experimental and computational study

Azines are having widespread applications in both industry as well as synthetic chemistry. Thus new catalytic synthetic protocols are desirable as they are greener alternatives than traditional methods of synthesis. Thus, herein a novel earth abundant nickel based NNN-pincer catalyst Ni(BPEA)(Cl2) is synthesized for the first time for the direct transformation of alcohols and hydrazine hydrate into symmetrical azines. This catalytic reaction is accompanied by dehydrogenative coupling of alcohols and hydrazine hydrate and is carried out in presence of a base. Theoretical calculations supported by experimental evidence have been performed for understanding the mechanistic insights of the reaction.

METHOD OF PRODUCING PHENOLIC COMPOUND

PROBLEM TO BE SOLVED: To provide a method of efficiently producing a phenolic compound by direct oxidation of an aromatic compound. SOLUTION: A phenolic compound is produced by oxidation of an aromatic compound by an oxidant in the presence of a binuclear nickel complex having a ligand being a compound represented by the formula (I) or (II) in the figure. SELECTED DRAWING: None COPYRIGHT: (C)2017,JPOandINPIT

Exploiting 1,2,3-Triazolium Ionic Liquids for Synthesis of Tryptanthrin and Chemoselective Extraction of Copper(II) Ions and Histidine-Containing Peptides

Based on a common structural core of 4,5,6,7-Tetrahydro[1,2,3]triazolo[1,5-A]pyridine, a number of bicyclic triazolium ionic liquids 1-3 were designed and successfully prepared. In our hands, this optimized synthesis of ionic liquids 1 and 2 requires no chromatographic separation. Also in this work, ionic liquids 1, 2 were shown to be efficient ionic solvents for fast synthesis of tryptanthrin natural product. Furthermore, a new affinity ionic liquid 3 was tailor-synthesized and displayed its effectiveness in chemoselective extraction of both Cu(II) ions and, for the first time, histidine-containing peptides.

Modification and optimization of the bis-picolylamide-based relay protection for carboxylic acids to be cleaved by unusual complexation with Cu2+ salts

A simple modification of our recently published protection scheme for carboxylic acids as amides resulted in a new protecting group with significantly improved properties. It requires shorter reaction times for deprotection and allows us to replace Cu(OTf)2 by CuCl2, indicating at the same time the importance of the nature of the anion of the Cu2+ source. Since the new scheme fulfills all criteria required for an ideal protection group it should find widespread application in synthetic organic chemistry.