6966-21-8

Usage

Chemical Properties

Solid

Uses

An intermediate for the synthesis of Tamoxifen

InChI:InChI=1/C16H16O2/c1-2-15(12-6-4-3-5-7-12)16(18)13-8-10-14(17)11-9-13/h3-11,15,17H,2H2,1H3

Upstream product

• 78423-10-6 1-(4-methoxyphenyl)-2-phenylbutan-1-one 
• 100-66-3 methoxybenzene 
• 90-27-7 2-Phenylbutyric acid 
• 14293-14-2 4-(benzyloxy)phenyl benzyl ketone 
• 2491-32-9 1-(4-Hydroxyphenyl)-2-phenylethanone 
• 70354-03-9 1-(4-benzyloxyphenyl)-2-phenyl-butan-1-one 

Downstream Products

• 74631-77-9 1-[4-(2-diethylamino-ethoxy)-phenyl]-2-phenyl-butan-1-one 
• 70354-02-8 1-<4-<(tetrahydropyran-2-yl)oxy>phenyl>-2-phenylbutan-1-one 
• 1189368-81-7 C₃₆H₄₄O₄Si 
• 1189368-80-6 C₂₂H₃₀O₂Si 
• 749-86-0 {2-[4-((Z)-1,2-Diphenyl-but-1-enyl)-phenoxy]-ethyl}-diethyl-amine 
• 10540-29-1 tamoxifen 
• 35258-20-9 Diethyl-(2-{4-[(Z)-1-(4-methoxy-phenyl)-2-phenyl-but-1-enyl]-phenoxy}-ethyl)-amine 
• 748-97-0 1-(4-(2-(dimethylamino)ethoxy)phenyl)-1,2-diphenylbutan-1-ol 
• 749-16-6 3-[4-(1,2-diphenylbut-1-en-1-yl)phenoxy]-N,N-dimethylpropan-1-amine 
• 68047-07-4 1-[4-[2-(N,N-dimethylamino)ethoxy]phenyl]-2-phenyl-1-butanone 

Relevant academic research and scientific papers

NOVEL COMPOUNDS

The present invention relates to novel compounds with a variety of therapeutic uses, more particularly novel prodrugs that are particularly useful for delivering a parent compound for selective estrogen receptor modulation.

1,1,2-TRIPHENYLBUT-1-ENE DERIVATIVES

Novel (E)-1-[4'-(2-alkylaminoethoxy)phenyl]-1-(3'-hydroxyphenyl)-2-phenylbut-1-enes of the general formula STR1 wherein R 1 and R. sup.2 may be the same or different, provided that, when R 1 and R 2 are the same, each of them is a methyl or ethyl radical, and when R 1 and R 2 are different, one of them is hydrogen and the other is a methyl or ethyl radical, and the therapeutically compatible salts thereof, have a marked anti-estrogenic effect and are suitable for treating hormone-dependent mammary tumors.The compounds can be prepared by dehydrating carbinols of the general formula STR2 wherein R 1 and R 2 may be the same or different, provided that, when R. sup.1 and R 2 are the same, each of them is a methyl or ethyl radical, and when R 1 and R 2 are different, one of them is a benzyl radical and the other is a methyl or ethyl radical; and wherein R 3 is hydrogen or an easily hydrolyzable protecting group, through the action of mineral acid while removing any protecting group present, isolating through crystallization the E-form from the pair of isomers obtained, and removing by hydrogenolysis any benzyl group present.Compositions comprising the subject 1,1,2-triphenylbut-1-ene derivatives are described also. The corresponding novel 1,1,2-triphenylbut-1-ene derivatives having the (Z) configuration are also disclosed.

Studies in Potential Antifertility Agents: Part XXIV - Synthesis of 2,3-Disubstituted 4'-(&β-dialkylaminoethoxy)propiophenones

A number of 2,3-disubstituted 4'-(β-dialkylaminoethoxy)propiophenones (32-41) have been synthesized as the structural analogs of a potent antifertility agent erythro-2,3-diphenyl-4'-(β-pyrrolidinoethoxy)valerophenone (1).Compounds 34, 35, 38 and 40 show cent per cent activity at dose levels of 2.5, 10, 10, 10 and 1 mg/kg, respectively.The structure activity relationship has also been discussed.