69660-39-5

Usage

Uses

Used in Polymer Production:
2,6-Dihydroxyterephthalic acid is used as a monomer in the production of polyester resins and fibers due to its ability to form polymer chains through esterification reactions. This application is crucial for creating materials with enhanced properties for various industrial uses.
Used in Pharmaceutical and Agrochemical Synthesis:
In the pharmaceutical and agrochemical industries, 2,6-Dihydroxyterephthalic acid is used as a key intermediate for the synthesis of diverse organic compounds. Its chemical structure allows for the development of new drugs and agrochemicals with specific therapeutic or pesticidal properties.
Used in Biodegradable Polymers:
2,6-Dihydroxyterephthalic acid is utilized as a precursor in the development of biodegradable polymers. These polymers are essential for creating environmentally friendly materials that can degrade over time, reducing plastic pollution and waste.
Used in Photoactive Material Synthesis:
As a precursor, 2,6-Dihydroxyterephthalic acid is also used in the synthesis of photoactive materials. These materials have applications in various fields, such as solar energy conversion, photodetectors, and light-emitting diodes, due to their ability to interact with light and convert it into other forms of energy.

Upstream product

• 99-10-5 3,5-Dihydroxybenzoic acid 
• 124-38-9 carbon dioxide 

Downstream Products

• 35416-55-8 dimethyl 2,6-dihydroxy-1,4-benzenedicarboxylate 
• 1352616-78-4 2,6-bis(2-methoxyethoxy)-1,4-benzenedicarboxylic acid 

Relevant academic research and scientific papers

First total synthesis of ampullosine, a unique isoquinoline alkaloid isolated from Sepedonium ampullosporum, and of the related permethylampullosine

A straightforward and convenient approach toward the first total synthesis of ampullosine, a structurally unique 3-methylisoquinoline alkaloid isolated from Sepedonium ampullosporum, is reported. Access to the related O-methyl ampullosine methyl ester from a common intermediate is also disclosed. The synthetic sequence toward the natural product comprised a Kolbe-type carboxylation of 3,5-dihydroxybenzoic acid and further esterification of the diacid, followed by masking of one of the phenols through selective ester reduction and subsequent acetonide formation. Installation of the three-carbon atom required for the 3-methylpyridine ring was performed by triflation of the remaining free phenol and a Pd-catalyzed Suzuki-Miyaura reaction with potassium E-propenyltrifluoroborate. Deprotection of the acetonide, followed by partial oxidation of the benzylic alcohol to the salicylaldehyde, O-methylation of the free phenol and hydrazonation of the resulting ortho-anisaldehyde derivative gave a hydrazone-based 1-azatriene. This was further subjected to 6π-azaelectrocyclization to afford permethylampullosine (11 steps, 14% overall yield), whereas exhaustive demethylation with AlI3 generated in situ gave ampullosine (12 steps, 3.2% global yield).

Inclusion complex containing epoxy resin composition for semiconductor encapsulation

The invention is an epoxy resin composition for sealing a semiconductor, including (A) an epoxy resin and (B) a clathrate complex. The clathrate complex is one of (b1) an aromatic carboxylic acid compound, and (b2) at least one imidazole compound represented by formula (II): wherein R2 represents a hydrogen atom, C1-C10 alkyl group, phenyl group, benzyl group or cyanoethyl group, and R3 to R5 represent a hydrogen atom, nitro group, halogen atom, C1-C20 alkyl group, phenyl group, benzyl group, hydroxymethyl group or C1-C20 acyl group. The composition has improved storage stability, retains flowability when sealing, and achieves an effective curing rate applicable for sealing delicate semiconductors.

Enantioselective total synthesis of (+)-stachyflin: A potential anti-influenza a virus agent isolated from a microorganism

A novel and potent hemagglutinin inhibitor, (+)-stachyflin, was efficiently synthesized in an enantioselective manner starting from the (+)-5-methyl-Wieland-Miescher ketone. The synthetic method features a BF 3·Et2O-induced cascade epoxide-opening/ rearrangement/cyclization reaction tostereoselectively construct the requisite pentacyclic ring system in one step. In order to rationalize the mechanism of the cascade reaction, quantum chemical calculations of the possible intermediary carbocations and transition states in the model synthesis were carried out. An alternative approach to synthesize (+)-stachyflin by employing a similar cascade reaction was also described. A potential anti-influenza A virus agent, (+)-stachyflin, a novel hemagglutinin inhibitor, has been synthesized in an enantioselective manner for the first time starting from (+)-5-methyl-Wieland- Miescher ketone. The method features a BF3·Et 2O-induced cascade epoxide-opening/rearrangement/cyclization reaction to construct the requisite pentacyclic ring system in one step.

Total synthesis of (+)-stachyflin: A potential anti-influenza A virus agent

The first enantioselective total synthesis of (+)-stachyflin, a potential anti-influenza A virus agent, was achieved; the method features a BF 3·Et2O-induced domino epoxide-opening/ rearrangement/cyclization reaction to stereoselecti