696603-01-7Relevant academic research and scientific papers
Identification of aminopiperidine benzamides as MCHr1 antagonists
Vasudevan, Anil,Verzal, Mary K.,Wodka, Derek,Souers, Andrew J.,Blackburn, Christopher,Che, Jennifer Lee,Lai, Sujen,Brodjian, Sevan,Falls, Doug H.,Dayton, Brian D.,Govek, Elizabeth,Daniels, Tom,Geddes, Brad,Marsh, Kennan C.,Hernandez, Lisa E.,Collins, Christine A.,Kym, Philip R.
, p. 3412 - 3416 (2007/10/03)
The identification of a novel series of benzamide-containing MCHr1 antagonists is described. Compound 22 displayed moderate efficacy in a diet induced obesity mice model.
Discovery and characterization of aminopiperidinecoumarin melanin concentrating hormone receptor 1 antagonists
Kym, Philip R.,Iyengar, Rajesh,Souers, Andrew J.,Lynch, John K.,Judd, Andrew S.,Gao, Ju,Freeman, Jennifer,Mulhern, Mathew,Zhao, Gang,Vasudevan, Anil,Wodka, Dariusz,Blackburn, Christopher,Brown, Jim,Che, Jennifer Lee,Cullis, Courtney,Lai, Su Jen,LaMarche, Matthew J.,Marsilje, Tom,Roses, Jon,Sells, Todd,Geddes, Brad,Govek, Elizabeth,Patane, Michael,Fry, Dennis,Dayton, Brian D.,Brodjian, Sevan,Falls, Doug,Brune, Michael,Bush, Eugene,Shapiro, Robin,Knourek-Segel, Victoria,Fey, Thomas,McDowell, Cathleen,Reinhart, Glenn A.,Preusser, Lee C.,Marsh, Kennan,Hernandez, Lisa,Sham, Hing L.,Collins, Christine A.
, p. 5888 - 5891 (2007/10/03)
4-(1-Benzo[1,3]dioxol-5-ylmethylpiperidine-4-ylmethyl)-6-chlorochromen-2- one (7) is a potent, orally bioavailable melanin concentrating hormone receptor 1 (MCHr1) antagonist that causes dose-dependent weight loss in diet-induced obese mice. Further evalu
