696604-60-1Relevant academic research and scientific papers
Eight-membered-ring diaminocarbenes bearing naphthalene moiety in the backbone: DFT studies, synthesis of amidinium salts, generation of free carbene, metal complexes, and solvent-free copper catalyzed azide-alkyne cycloaddition (CuAAC) reaction
Chesnokov, Gleb A.,Topchiy, Maxim A.,Dzhevakov, Pavel B.,Gribanov, Pavel S.,Tukov, Aleksandr A.,Khrustalev, Victor N.,Asachenko, Andrey F.,Nechaev, Mikhail S.
, p. 4331 - 4345 (2017)
A new type of eight-membered ring N-heterocyclic carbene (NHC) bearing a rigid naphthalene moiety in the backbone is reported for the first time. Stereoelectronic properties of 4,5-dihydro-1H-naphtho[1,8-ef][1,3]diazocin-3(2H)-ylidene (NaphtDHD) and small
One-pot synthesis of 1-monosubstituted-1, 2, 3-triazoles from 2-methyl-3-butyn-2-ol
Liu, Yaowen,Han, Chunmei,Ma, Xinyuan,Yang, Jianhua,Feng, Xuepu,Jiang, Yubo
supporting information, p. 650 - 653 (2018/01/15)
An efficient method for the synthesis of 1-monosubstituted-1, 2, 3-triazoles from 2-methyl-3-butyn-2-ol under copper catalyst conditions has been developed through a one-step one-pot sequence. This method provides a concise and efficient pathway to synthesize 1-monosubstituted-1, 2, 3-triazole derivatives in good to excellent yields.
Synthesis, anticlotting and antiplatelet effects of 1,2,3-triazoles derivatives
Moura, Laura De A.,De Almeida, Ana C. M.,Da Silva, Andreza V.,De Souza, Vivian R.,Ferreira, Vitor F.,Menezes, Michel V.,Kaiser, Carlos R.,Ferreira, Sabrina B.,Fuly, André L.
, p. 733 - 741 (2016/11/29)
Background: Cardiovascular diseases, such as thrombosis and stroke, represent the major cause of disability and death worldwide; and dysfunctions in platelet aggregation and blood coagulation processes are involved. The regular antithrombotic drugs have u
Synthesis of 1,2,3-triazole derivatives and in Vitro antifungal evaluation on Candida strains
Lima-Neto, Reginaldo G.,Cavalcante, Nery N. M.,Srivastava, Rajendra M.,Mendonca Jr., Francisco J. B.,Wanderley, Almir G.,Neves, Rejane P.,Dos Anjos, Janaina V.
, p. 5882 - 5892 (2012/09/22)
1,2,3-Triazoles have been extensively studied as compounds possessing important biological activities. In this work, we describe the synthesis of ten 2-(1-aryl-1H- 1,2,3-triazol-4-yl)propan-2-ols via copper catalyzed azide alkyne cycloaddition (CuAAc or click chemistry). Next the in vitro antifungal activity of these ten compounds was evaluated using the microdilution broth method against 42 isolates of four different Candida species. Among all tested compounds, the halogen substituted triazole 2-[1-(4-chlorophenyl)-1H- (1,2,3)triazol-4-yl]propan-2-ol, revealed the best antifungal profile, showing that further modifications could be done in the structure to obtain a better drug candidate in the future.
