69663-19-0Relevant academic research and scientific papers
Pyridinium p-DSSC dyes: An old acceptor learns new tricks
Marri, Anil Reddy,Black, Fiona A.,Mallows, John,Gibson, Elizabeth A.,Fielden, John
, p. 508 - 517 (2019/03/17)
A family of six (five new) thiophenyl bridged triarylamine-donor based dyes with pyridine anchoring groups have been synthesized and studied as sensitizers for the p-type dye-sensitized solar cell (p-DSSC). They comprise bis-dicyano acceptor systems with
Synthesis, characterization, and evaluation of cis-diphenyl pyridineamine platinum(II) complexes as potential anti-breast cancer agents
Gamboa Varela, Jacqueline,De Chatterjee, Atasi,Guevara, Priscilla,Ramirez, Verenice,Metta-Maga?a, Alejandro J.,Villagrán, Dino,Varela-Ramirez, Armando,Das, Siddhartha,Nu?ez, Jose E.
, p. 967 - 979 (2014/08/18)
Although cisplatin is considered as an effective anti-cancer agent, it has shown limitations and may produce toxicity in patients. Therefore, we synthesized two cis-dichlorideplatinum(II) compounds (13 and 14) composed of meta- and para-N,N-diphenyl pyridineamine ligands through a reaction of the amine precursors and PtCl2 with respective yields of 16 and 47 %. We hypothesized that compounds 13 and 14, with lipophilic ligands, should transport efficiently in cancer cells and demonstrate more effectiveness than cisplatin. When tested for biological activity, compounds 13 and 14 were found to inhibit the growth of MCF 7 and MDA-MB-231 cells (IC50s 1 ± 0.4 μM and 1 ± 0.2 μM for 13 and 14, respectively, and IC50 7.5 ± 1.3 μM for compound 13 and 1 ± 0.3 μM for compound 14). Incidentally, these doses were found to be lower than cisplatin doses (IC 50 5 ± 0.7 μM for MCF 7 and 10 ± 1.1 μM for MDA-MB-231). Similar to cisplatin, 13 and 14 interacted with DNA and induced apoptosis. However, unlike cisplatin, they blocked the migration of MDA-MB-231 cells suggesting that in addition to apoptotic and DNA-binding capabilities, these compounds are useful in blocking the metastatic migration of breast cancer cells. To delineate the mechanism of action, computer-aided analyses (DFT calculations) were conducted for compound 13. Results indicate that in vivo, the pyridineamine ligands are likely to dissociate from the complex, forming a platinum DNA adduct with anti-proliferative activity. These results suggest that complexes 13 and 14 hold promise as potential anti-cancer agents.
NEW APPLICATION OF COMPLEX BASES: NUCLEOPHILIC CONDENSATIONS OF PYRIDINE
Jamart-Gregoire, Brigitte,Leger, Christian,Caubere, Paul
, p. 7599 - 7602 (2007/10/02)
3,4-Dehydropyridine can be easily generated from 3-bromopyridine by complex bases.Nucleophilic condensations of amines, ketones and nitrile enolates are thus performed for the first time in good to very good yields.
Synthetic Applications of N-N Linked Heterocycles. Part 15. A Facile Synthesis of 4-Pyridyl(aryl)amines via the Reaction between 4-Chloro-1-pyridiniopyridinium Salts and Aryl Amines
Sammes, Michael P.,Ho, King-Wah,Tam, Ming-Lim,Katritzky, Alan R.
, p. 973 - 978 (2007/10/02)
4-Chloro-1-pyridiniopyridinium salts (7) and (8) react with primary and secondary arylamines to give high yields of isolable 4-aryliminium salts (9) and (10).These are readily fragmented into 4-pyridyl(aryl)amines (11) and (12) in excellent yields on treatment with sodium cyanide or sodium salts of sulphonic acids.The method fails with the more basic aliphatic amines, since these apparently attack the 2-position of the chloropyridinium ring giving products resulting from ring-opening.Mechanisms of the reactions are discussed.
